Reference : New Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos Icaja Roots
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/6327
New Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos Icaja Roots
English
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Gillet, Marie-Claire mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques >]
Llabres, Gabriel mailto [Université de Liège - ULg > Département de physique > Département de physique >]
Tits, Monique mailto [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
Hayette, Marie-Pierre mailto [Université de Liège - ULg > > Microbiologie médicale >]
Brandt, Viviane [> > > >]
Penelle, Jacques [> > > >]
De Mol, Patrick mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Apr-2000
Planta Medica
66
3
262-9
Yes (verified by ORBi)
International
0032-0943
[en] indolomonoterpenoid ; indole alkaloid ; antiplasmodial ; bisindolic ; malaria ; plasmodium falciparum
[en] Reinvestigation of Strychnos icaja Baillon resulted in the isolation of vomicine, isostrychnine and of three new sungucine derivatives, named isosungucine (8), 18-hydroxy-sungucine (9) and 18-hydroxy-isosungucine (10). They were identified by detailed spectroscopic methods. The complete 1H- and 13C-NMR study of sungucine was also realized. Some of these compounds were highly active against Plasmodium falciparum in vitro and more particularly against the chloroquine-resistant strain. Compound 10 showed a selective antiplasmodial activity, with > 100-fold greater toxicity towards Plasmodium falciparum, relative to cultured human cancer cells (KB and HeLa lines) or fibroblasts (WI38).
http://hdl.handle.net/2268/6327

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