ORBi: Frederich Michel - New Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos Icaja Roots

Reference : New Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos Icaja Roots


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology
	To cite this reference:	http://hdl.handle.net/2268/6327

Title :	New Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos Icaja Roots
Language :	English
Author, co-author :	Frederich, Michel [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
	Gillet, Marie-Claire [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques >]
	Llabres, Gabriel [Université de Liège - ULg > Département de physique > Département de physique >]
	Tits, Monique [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
	Hayette, Marie-Pierre [Université de Liège - ULg > > Microbiologie médicale >]
	Brandt, Viviane [> > > >]
	Penelle, Jacques [> > > >]
	De Mol, Patrick [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale]
	Angenot, Luc [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Publication date :	Apr-2000
Journal title :	Planta Medica
Volume :	66
Issue/season :	3
Pages :	262-9
Audience :	International
ISSN :	0032-0943
Keywords :	[en] indolomonoterpenoid ; indole alkaloid ; antiplasmodial ; bisindolic ; malaria ; plasmodium falciparum
Abstract :	[en] Reinvestigation of Strychnos icaja Baillon resulted in the isolation of vomicine, isostrychnine and of three new sungucine derivatives, named isosungucine (8), 18-hydroxy-sungucine (9) and 18-hydroxy-isosungucine (10). They were identified by detailed spectroscopic methods. The complete 1H- and 13C-NMR study of sungucine was also realized. Some of these compounds were highly active against Plasmodium falciparum in vitro and more particularly against the chloroquine-resistant strain. Compound 10 showed a selective antiplasmodial activity, with > 100-fold greater toxicity towards Plasmodium falciparum, relative to cultured human cancer cells (KB and HeLa lines) or fibroblasts (WI38).
Permalink :	http://hdl.handle.net/2268/6327

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	sungucines.pdf	No commentary	Publisher postprint	168.98 kB	Request copy

All documents in ORBi are protected by a user license.

Dspace v1.5