Reference : Comparative immunohistochemical study of herpes-simplex and varicella-zoster infections
Scientific journals : Article
Human health sciences : Immunology & infectious disease
Human health sciences : Dermatology
Comparative immunohistochemical study of herpes-simplex and varicella-zoster infections
Nikkels, Arjen mailto [Centre Hospitalier Universitaire de Liège – CHU > > Dermatopathologie >]
Debrus, S. [> > > >]
Sadzot-Delvaux, Catherine mailto [Université de Liège - ULg > Département des sciences de la vie > Virologie et immunologie - GIGA-M : Coordination scientifique >]
Piette, Jacques [Université de Liège - ULg > Département des sciences de la vie > Virologie - Immunologie >]
Delvenne, Philippe [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Rentier, Bernard mailto [Université de Liège - ULg > Département de Microbiologie > Virologie fondamentale et Immunologie > >]
Pierard, Gérald [Université de Liège - ULg > Département des sciences cliniques > Dermatopathologie >]
Virchows Archiv. A : Pathological Anatomy and Histopathology
Springer verlag
Yes (verified by ORBi)
[en] Immunohistochemistry ; Skins ; Herpes ; Varicella-zoster ; Vasculitis
[en] Herpes simplex (HSV) and varicella-zoster (VZV) skin infections share so many histological similarities that distinguishing between them may prove to be impossible. We developed and characterized a new monoclonal antibody, VL8, IgG kappa isotype, directed to the VZV envelope glycoprotein gpI. Immunohistochemistry with VL8 appeared highly sensitive and specific on formalin-fixed paraffin-embedded biopsies and a clear-cut distinction between HSV and VZV infections was possible. The pattern of VL8 immunolabelling in VZV infections was strikingly different from that found in HSV infections studied with polyclonal antibodies to HSV I and II. Double immunolabelling revealed the VL8 positivity of sebaceous cells, endothelial cells, Mac 387-and CD68-positive monocyte-macrophages, and factor XIIIa-positive perivascular, perineural and interstitial dendrocytes. Intracytoplasmic VL8 labelling of endothelial cells and perivascular dendrocytes was found at the site of leukocytoclastic vasculitis.
Researchers ; Professionals
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