Reference : Antimicrobial activity against gram negative bacilli from Yaounde Central Hospital, C...
Scientific journals : Article
Life sciences : Microbiology
http://hdl.handle.net/2268/63125
Antimicrobial activity against gram negative bacilli from Yaounde Central Hospital, Cameroon
English
Gangoue Pieboji, Joseph mailto [Institut de Recherches Médicales et d'étude des plantes médicinales-IMPM-Cameroun > > > >]
Koulla-Shiro, S. [> > > >]
Ngassam, P. [> > > >]
Adiogo, D. [> > > >]
Ndumbe, P. [> > > >]
2006
African Health Sciences
6
4
232-5
Yes (verified by ORBi)
International
1680-6905
1729-0503
[en] Anti-Infective Agents/administration & dosage/pharmacology/*therapeutic ; use ; Cameroon ; *Drug Resistance, Bacterial ; Gram-Negative Bacteria/*drug effects/isolation & purification ; Humans ; Microbial Sensitivity Tests
[en] BACKGROUND: Antimicrobial resistance among bacteria pathogens is a world-wide issue. The antimicrobial susceptibility patterns of common pathogenic bacteria are essential to guide empirical and pathogen-specific therapy; unfortunately, these data are scarse in Cameroon. OBJECTIVE: To determine the antimicrobial susceptibility patterns of Gram-negative bacilli isolated in Yaounde Central Hospital Laboratory of Bacteriology. METHODS: Gram-negative bacilli isolates (n = 505), obtained from a wide range of clinical specimens (urine, pus and blood) in Yaounde Central Hospital Laboratory of Bacteriology between March 1995 and April 1998, were evaluated for resistance to antibiotics (amoxicillin, amoxicillin/clavulanate, piperacillin, cefazolin, cefoxitin, cefotaxime, ceftazidime, aztreonam, imipenem, gentamicin, tobramicin, ofloxacin and trimethoprim/sulfamethoxazole) by the Kirby-Bauer disk diffusion method. RESULTS: High rates of resistance were found in most of the bacteria studied. Resistance to all isolates was mostly observed for amoxicillin (87%), piperacillin (74%) and trimethoprim/sulfamethoxazole (73%). Susceptibilities to third generation cephalosporins (cefotaxime, ceftazidime) and monobactame (aztreonam) were = 91% for Escherichia coli, = 71% for Klebsiella spp., = 98% for Proteus mirabilis, = 50% for Enterobacter spp. and Citrobacter spp. Pseudomonas aeruginosa was less susceptible to cefotaxime (2%) and aztreonam (33%), and highly susceptible to ceftazidime (72%) whereas Acinetobacter baumannii was highly resistant to aztreonam (100%), to cefotaxime (96%) and cetazidime (62%). Imipenem (98%) was the most active antibiotic followed by the ofloxacine (88%). Susceptibility of all isolates to gentamicin was 67%. CONCLUSION: These results indicate that surveillance to antimicrobial resistance in Cameroon is necessary to monitor microbial trends, antimicrobial resistance pattern, and provide information for choosing empirical or direct therapy to physicians.
http://hdl.handle.net/2268/63125
10.5555/afhs.2006.6.4.232
2007/07/03

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