Article (Scientific journals)
Vimentin Expression in Cervical Carcinomas: Association with Invasive and Migratory Potential
Gilles, Christine; Polette, M.; Piette, Jacques et al.
1996In Journal of Pathology, 180 (2), p. 175-80
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Abstract :
[en] Vimentin is an intermediate filament protein normally expressed in mesenchymal cells, but evidence is accumulating in the literature which suggests that the aberrant expression of vimentin in epithelial cancer cells might be related to local invasiveness and metastatic potential. Vimentin expression has previously been associated with invasive properties in an in vitro model consisting of a set of HPV-33-transformed cervical keratinocyte cell lines. In the present study, in order to emphasize those in vitro findings, the expression of vimentin has been investigated in cervical neoplasms of different grades, using immunohistochemistry. A clear association is reported between vimentin expression and metastatic progression, since vimentin was detected in all invasive carcinomas and lymph node metastases, but not in CIN III lesions. These in vivo results are compared with present and previous data obtained in vitro on cervical keratinocyte cell lines, where vimentin expression also correlated with in vitro invasiveness.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Gilles, Christine ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Polette, M.
Piette, Jacques ;  Université de Liège - ULiège > Département des sciences de la vie > Virologie - Immunologie
Delvigne, A. C.
Thompson, E. W.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Birembaut, P.
Language :
English
Title :
Vimentin Expression in Cervical Carcinomas: Association with Invasive and Migratory Potential
Publication date :
October 1996
Journal title :
Journal of Pathology
ISSN :
0022-3417
eISSN :
1096-9896
Publisher :
John Wiley & Sons, Inc, Chichester, United Kingdom
Volume :
180
Issue :
2
Pages :
175-80
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 June 2010

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