Reference : Erythropoiesis after nonmyeloablative stem-cell transplantation is not impaired by inade...
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/6297
Erythropoiesis after nonmyeloablative stem-cell transplantation is not impaired by inadequate erythropoietin production as observed after conventional allogeneic transplantation.
English
Baron, Frédéric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Fillet, Georges mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Beguin, Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
2002
Transplantation
Lippincott Williams & Wilkins
74
12
1692-6
Yes (verified by ORBi)
International
0041-1337
1534-6080
Hagerstown
MD
[en] Adult ; Cyclosporine/administration & dosage/blood ; Erythropoiesis/drug effects/physiology ; Erythropoietin/biosynthesis/blood/deficiency ; Erythropoietin, Recombinant/administration & dosage ; Female ; Graft Rejection/drug therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunosuppressive Agents/administration & dosage/blood ; Leukemia/therapy ; Lymphoma/therapy ; Male ; Middle Aged ; Mycophenolic Acid/administration & dosage/analogs & derivatives ; Receptors, Transferrin/blood ; Transplantation Conditioning ; Transplantation, Homologous
[en] BACKGROUND: It is now well established that after conventional allogeneic hematopoietic stem-cell transplantation (HSCT), erythropoietic recovery is impaired because erythropoietin (Epo) production remains inadequate for prolonged periods of time. However, erythropoietic reconstitution after nonmyeloablative SCT (NMSCT) has never been characterized. METHODS: Twelve patients received a nonmyeloablative conditioning regimen consisting of 2 Gy total body irradiation (TBI) alone (n=6), 2 Gy TBI and fludarabine (n=3), or cyclophosphamide and fludarabine (n=3), followed by transplantation of allogeneic peripheral blood stem cells. Graft-versus-host-disease (GvHD) prophylaxis was carried out with mycophenolate mofetil (from day -1 to day 28) plus cyclosporine (from day -1 to day 120 or longer in case of chronic GvHD). Erythropoiesis was quantitated by soluble transferrin receptor (sTfR) levels, and the adequacy of Epo production was evaluated by the observed-to-predicted Epo ratio (O/P Epo). RESULTS: Mean sTfR levels decreased following the conditioning regimen but remained well within the normal range throughout the posttransplant period. The O/P Epo ratio presented an initial surge quite similar to that observed after conventional conditioning. Thereafter, the O/P Epo ratio normalized rapidly, and Epo levels remained adequate during the whole observation period. CONCLUSION: Contrarily to what is observed after myeloablative transplant, Epo levels remained adequate after NMSCT, resulting in normal erythropoiesis. These results suggest that the administration of erythropoietin therapy (rHuEpo) could be less effective after NMSCT than after conventional allogeneic transplant.
http://hdl.handle.net/2268/6297
10.1097/01.TP.0000038728.65545.FE

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