Reference : Multiple feedback loops in circadian cycles: robustness and entrainment as selection cri...

	Document type :	Scientific congresses and symposiums : Paper published in a book
	Discipline(s) :	Engineering, computing & technology : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/2268/62863

Title :	Multiple feedback loops in circadian cycles: robustness and entrainment as selection criteria
Language :	English
Author, co-author :	Hafner, Marc [> >]
	Sacré, Pierre [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
	Symul, Laura [> >]
	Sepulchre, Rodolphe [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
	Koeppl, Heinz [> >]
Publication date :	Jun-2010
Main document title :	Proceedings of the Seventh International Workshop on Computational Systems Biology, WCSB 2010
Peer reviewed :	Yes
Audience :	International
Event name :	Seventh International Workshop on Computational Systems Biology, WCSB 2010
Event date :	June 16-18, 2010
Event place (city) :	Luxembourg
Event country :	Luxembourg
Abstract :	[en] This paper discusses the contribution of an additional feedback loop to the entrainment and the robustness of a circadian system. To quantify robustness, we perform a global analysis of the system's parameter space. We quantify the parameter region where the circuit displays an experimentally observed behavior, under entrainment. This global measure is comleted with a classification based on the phase response curve (PRC). For two models of circadian rhythms, we found that the one with two loops is more robust than the one with a single loop: the two-loop model shows better resilience to parameter perturbations and it has also a larger region where the PRC matches experimental PRCs of circadian oscillators.
Permalink :	http://hdl.handle.net/2268/62863

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	Fulltext file(s): File Commentary Version Size Access Open access hssks_WCSB2010_v3.pdf Author preprint 82.17 kB View/Open

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