[en] This paper discusses the contribution of an additional feedback loop to the entrainment and the robustness of a circadian system. To quantify robustness, we perform a global analysis of the system's parameter space. We quantify the parameter region where the circuit displays an experimentally observed behavior, under entrainment. This global measure is comleted with a classification based on the phase response curve (PRC). For two models of circadian rhythms, we found that the one with two loops is more robust than the one with a single loop: the two-loop model shows better resilience to parameter perturbations and it has also a larger region where the PRC matches experimental PRCs of circadian oscillators.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Hafner, Marc
Sacré, Pierre ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Symul, Laura
Sepulchre, Rodolphe ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Koeppl, Heinz
Language :
English
Title :
Multiple feedback loops in circadian cycles: robustness and entrainment as selection criteria
Publication date :
June 2010
Event name :
Seventh International Workshop on Computational Systems Biology, WCSB 2010
Event place :
Luxembourg, Luxembourg
Event date :
June 16-18, 2010
Audience :
International
Main work title :
Proceedings of the Seventh International Workshop on Computational Systems Biology, WCSB 2010