Reference : Multiple feedback loops in circadian cycles: robustness and entrainment as selection ...
Scientific congresses and symposiums : Paper published in a book
Engineering, computing & technology : Multidisciplinary, general & others
http://hdl.handle.net/2268/62863
Multiple feedback loops in circadian cycles: robustness and entrainment as selection criteria
English
Hafner, Marc [> >]
Sacré, Pierre mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Symul, Laura [> >]
Sepulchre, Rodolphe mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Koeppl, Heinz [> >]
Jun-2010
Proceedings of the Seventh International Workshop on Computational Systems Biology, WCSB 2010
Yes
International
Seventh International Workshop on Computational Systems Biology, WCSB 2010
June 16-18, 2010
Luxembourg
Luxembourg
[en] This paper discusses the contribution of an additional feedback loop to the entrainment and the robustness of a circadian system. To quantify robustness, we perform a global analysis of the system's parameter space. We quantify the parameter region where the circuit displays an experimentally observed behavior, under entrainment. This global measure is comleted with a classification based on the phase response curve (PRC). For two models of circadian rhythms, we found that the one with two loops is more robust than the one with a single loop: the two-loop model shows better resilience to parameter perturbations and it has also a larger region where the PRC matches experimental PRCs of circadian oscillators.
http://hdl.handle.net/2268/62863

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