Reference : Large-pore membrane hemofiltration increases cytokine clearance and improves right ve...
Scientific journals : Article
Human health sciences : Urology & nephrology
Human health sciences : Laboratory medicine & medical technology
http://hdl.handle.net/2268/6275
Large-pore membrane hemofiltration increases cytokine clearance and improves right ventricular-vascular coupling during endotoxic shock in pigs
English
Lambermont, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Delanaye, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
Dogné, Jean-Michel [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Ghuysen, Alexandre mailto [Université de Liège - ULg > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière]
Janssen, Nathalie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Urgences >]
Dubois, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
Desaive, Thomas mailto [Université de Liège - ULg > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles >]
Kolh, Philippe mailto [Université de Liège - ULg > Département des Sciences biomédicales et précliniques > Service de Biochimie et de Physiologie > >]
D'Orio, Vincenzo mailto [Université de Liège - ULg > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path.]
Krzesinski, Jean-Marie mailto [Université de Liège - ULg > Département des sciences cliniques > Néphrologie >]
Jul-2006
Artificial Organs
Blackwell Publishing
30
7
560-564
Yes (verified by ORBi)
International
0160-564X
Oxford
[en] cytokine ; endotoxin ; hemofiltration ; pulmonary circulation ; septic shock
[en] Hemodynamic improvement in patients suffering from both septic shock and renal failure who received hemofiltration suggested that an extrarenal epuration technique could be of interest in patients with septic shock alone. However, most of the studies using continuous venovenous hemofiltration (CVVH) in this setting evidenced neither cytokine clearance nor significant reduction in their plasma level. Lack of significant clearance was explained in part by the small size of the membrane pores. Therefore, we investigated the effects of large-pore membrane hemofiltration (LPHF) during endotoxic shock in pigs on interleukin 6 (IL-6) and interleukin 10 (IL-10) clearances, and on right ventricular (RV)-vascular coupling. Thirteen anesthetized healthy pigs weighing 20-30 kg were divided into two groups. In the Endo group (n = 6), the pigs received a 0.5-mg/kg endotoxin infusion over a period of 30 mins from T0 to T30. In the EndoHF group (n = 7), LPHF (cutoff = 80 kDa) and an ultrafiltration rate of 45 mL/kg/h were started 30 mins after the end of the endotoxin infusion, from T60 to T240. In this model of porcine endotoxic shock, LPHF was responsible for a significant clearance of IL-6 (20 mL/min) and Il-10 (14 mL/min), and for an improvement in RV-vascular coupling.
http://hdl.handle.net/2268/6275
10.1111/j.1525-1594.2006.00260.x
All our thank to Blackwell Publishing and Artificila Organs. The definitive version is available at www.blackwell-synergy.com

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