Reference : Is cystatin C useful for the detection and the estimation of low glomerular filtratio...
Scientific journals : Article
Human health sciences : Urology & nephrology
http://hdl.handle.net/2268/6272
Is cystatin C useful for the detection and the estimation of low glomerular filtration rate in heart transplant patients?
English
Delanaye, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
Nellessen, Eric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
Cavalier, Etienne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
Depas, Gisèle mailto [Centre Hospitalier Universitaire de Liège - CHU > > Médecine nucléaire >]
Grosch, Stéphanie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Defraigne, Jean-Olivier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie générale]
Chapelle, Jean-Paul mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Krzesinski, Jean-Marie mailto [Université de Liège - ULg > Département des sciences cliniques > Néphrologie >]
Lancellotti, Patrizio mailto [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
15-Mar-2007
Transplantation
Lippincott Williams & Wilkins
83
5
641-644
Yes (verified by ORBi)
International
0041-1337
Philadelphia
[en] glomerular filtration rate ; cystatin C ; creatinine ; modification of diet in renal disease
[en] Although previously studied in patients with chronic kidney disease, there is less data for the use of cystatin C and cystatin C-based formulas in heart transplant recipients. The ability of creatinine and cystatin C to detect renal failure (glomerular filtration rate [GFR] below 60 mL/min/1.73 m(2)) in heart transplant patients has been compared. The accuracy and precision of a creatinine-based formula (Modification of Diet in Renal Disease [MDRD]) versus a cystatin C-based formula (Rule's formula) to estimate GFR have also been studied. GFR was measured using the (51)Crethylenediamine tetraacetic acid tracer in 27 patients. There was no significant difference between GFR and the reciprocal of creatinine or cystatin C. Receiver operating characteristic curves for cystatin C and creatinine were similar. Both formulas were well correlated with the GFR. The bias of the cystatin C-based was significantly better than one of the MDRD formula, but the standard deviation appeared better for the MDRD formula (bias of +3.9 mL/min/1.73 m(2) versus +12 mL/min/1.73 m(2) and SD of 8.5 versus 11.6, respectively). Plasma cystatin C has no clear advantage over serum creatinine to detect renal failure in heart transplanted patients.
http://hdl.handle.net/2268/6272
10.1097/01.tp.0000253746.30273.cd
http://www.transplantjournal.com/pt/re/transplantation/abstract.00007890-200703150-00020.htm;jsessionid=JK3YXhC7vnz2hyVkQscwpnc21BY243PPGXRXS1kVsyGgFj6hvPDG!-450575803!181195629!8091!-1
All of our thanks to Lippincott, Williams & Wilkins. This is not the final version.

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