Differential expression of vascular endothelial growth factor and its receptors in hematopoietic and fatty bone marrow: evidence that neuropilin-1 is produced by fat cells.
[en] Vascular endothelial growth factor (VEGF), its receptors (VEGFR-1, VEGFR-2) and neuropillin-1 (NRP-1) are expressed at variable levels in bone marrow. NRP-1expression is higher in fatty bone marrow than in hematopoietic marrow. Adipocytes are responsible for NRP-1 expression suggesting that they may play a role in hematopoiesis by producing NRP-1 or that NRP-1 may regulate adipocyte activity.
Research center :
Service Histologie-Cytologie
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Belaid, Zakia ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Hubint, Frederique
Humblet, Chantal ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Boniver, Jacques ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Nusgens, Betty ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Laboratoire de Biologie des Tissus Conjonctifs
Defresne, Marie-Paule ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Language :
English
Title :
Differential expression of vascular endothelial growth factor and its receptors in hematopoietic and fatty bone marrow: evidence that neuropilin-1 is produced by fat cells.
Alternative titles :
[en] Expression différentielle du facteur de croissance vasculaire et ses récepteurs dans la moelle hématopoïétique et graisseuse: Une évidence de l'expression de la neuropilin-1 par les cellules graisseuses
Gerber HP, Ferrara N. The role of VEGF in normal and neoplastic hematopoiesis. J Mol Med 2003;81:20-31.
Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998; 92:735-45.
Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 1979;18:5294-9.
Lambert CA, Colige CA, Munaut C, Lapière CM, Nusguens BV. Distinct pathways in the over-expression of matrix metalloprotreinases in human fibroblasts by relaxation of mechanical tension. Matrix Biology 2001;20:397-408.
Kerndrup G, Pallesen G, Melsen F, Mosekilde L. Histomorphometrical determination of bone marrow cellularity in iliac crest biopsies. Scand J Haematol 1980;24:110-4.
Bellamy WT, Richter L, Frutiger Y, Grogan TM. Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies. Cancer Res 1999;59:728-33.
Ziegler BL, Valtieri M, Porada GA, De Maria R, Muller R, Masella B, et al. KDR receptor: a key marker defining hematopoietic stem cells. Science 1999;285:1553-8.
Emoto M, Anno T, Sato Y, Tanabe K, Okuya S, Tanizawa Y, et al. Troglitazone treatment increases plasma vascular endothelial growth factor in diabetic patients and its mRNA in 3T3-L1 adipocytes. Diabetes 2001;12:1166-70.
Tordjman R, Ortega N, Coulombel L, Plouet J, Romeo PH, Lemarchandel V. Neuropilin-1 is expressed on bone marrow stromal cells: a novel interaction with hematopoietic cells? Blood 1999;94:2301-9.