Article (Scientific journals)
Circulating erythropoietin levels after bone marrow transplantation: inappropriate response to anemia in allogeneic transplants.
Beguin, Yves; Clemons, G. K.; Oris, Renée et al.
1991In Blood, 77 (4), p. 868-73
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Keywords :
Adolescent; Adult; Anemia/blood; Bone Marrow Transplantation/adverse effects; Child; Child, Preschool; Cytomegalovirus Infections/blood/etiology; Erythropoietin/blood; Female; Graft Survival; Graft vs Host Disease/blood; Hematocrit; Hematologic Diseases/surgery; Humans; Male; Middle Aged; Transplantation, Autologous; Transplantation, Homologous
Abstract :
[en] We studied 24 recipients of autologous bone marrow transplantation (ABMT) or allogeneic BMT (BMT) to determine whether impaired erythropoietin (Epo) response to anemia could delay full erythropoietic recovery. Observed Epo levels were compared with predicted levels based on the relationship between Epo and hematocrit in 125 control subjects. Circulating Epo levels were normal during conditioning and the early posttransplant period. Between days 21 and 180, Epo levels remained normal in ABMT patients but were inappropriately low for the degree of anemia in BMT patients. Median time to full erythropoietic engraftment was longer in BMT than in ABMT recipients. Circulating Epo returned to appropriate levels after day 180, except in patients with active cytomegalovirus infection. We conclude that impaired Epo response to anemia can contribute to delayed erythropoietic recovery after allogenic BMT. Renal toxicity of ciclosporin, interaction between host and donor marrow, and cytomegalovirus infection might play a role. This study could support the use of recombinant human Epo to accelerate erythropoietic engraftment after BMT.
Disciplines :
Hematology
Author, co-author :
Beguin, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Clemons, G. K.
Oris, Renée ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Fillet, Georges ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Language :
English
Title :
Circulating erythropoietin levels after bone marrow transplantation: inappropriate response to anemia in allogeneic transplants.
Publication date :
1991
Journal title :
Blood
ISSN :
0006-4971
eISSN :
1528-0020
Publisher :
American Society of Hematology, Washington, United States - District of Columbia
Volume :
77
Issue :
4
Pages :
868-73
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 February 2009

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