Reference : Relation between disease phenotype and HLA-DQ genotype in diabetic patients diagnosed in...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/6254
Relation between disease phenotype and HLA-DQ genotype in diabetic patients diagnosed in early adulthood
English
Weets, Ilse [Vrije Universiteit Brussel - VUB > Diabetes Research Center (I.W., B.K., F.C.S., B.V.D.A., M.R., P.D.P., F.K.G.) > > >]
Siraux, Valérie [Cliniques Universitaires de Bruxelles - Hôpital Erasme > Department of Endocrinology (V.S., F.F.) > > >]
Daubresse, Jean-Claude [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
De Leeuw, Ivo H. [Universitair Ziekenhuis Antwerpen - UZA > Department of Endocrinology (I.H.D.L., L.V.G.) > > >]
Féry, Françoise [Cliniques Universitaires de Bruxelles - Hôpital Erasme > Department of Endocrinology (V.S., F.F.) > > >]
Keymeulen, Bart [Vrije Universiteit Brussel - VUB > Diabetes Research Center (I.W., B.K., F.C.S., B.V.D.A., M.R., P.D.P., F.K.G.) > > >]
Krzentowski, Georges [Centre Hospitalier Universitaire Charleroi > Department of Endocrinology (J.-C.D., G.K.) > > >]
Letiexhe, Michel mailto [Centre Hospitalier Universitaire de Liège - CHU > > Maladies infectieuses et médecine interne générale >]
Mathieu, Chantal mailto [Universitair Ziekenhuizen Leuven - UZ Leuven > Department of Endocrinology (C.M.) > > >]
Nobels, Frank [OLV Ziekenhuis Aalst > Department of Endocrinology (F.N.) > > >]
Rottiers, Raoul [Universitair Ziekenhuis Gent - UZ > Department of Endocrinology (R.R.) > > >]
Scheen, André mailto [Université de Liège - ULg > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale]
Van Gaal, Luc mailto [Universitair Ziekenhuis Antwerpen > Department of Endocrinology (I.H.D.L., L.V.G.) > > >]
Schuit, Frans C. [Vrije Universiteit Brussel - VUB > Diabetes Research Center (I.W., B.K., F.C.S., B.V.D.A., M.R., P.D.P., F.K.G.) > > >]
Van Der Auwera, Bart [Vrije Universiteit Brussel - VUB > Diabetes Research Center (I.W., B.K., F.C.S., B.V.D.A., M.R., P.D.P., F.K.G.) > > >]
Rui, Mao [Vrije Universiteit Brussel - VUB > Diabetes Research Center (I.W., B.K., F.C.S., B.V.D.A., M.R., P.D.P., F.K.G.) > > >]
De Pauw, Peter [Vrije Universiteit Brussel - VUB > Diabetes Research Center (I.W., B.K., F.C.S., B.V.D.A., M.R., P.D.P., F.K.G.) > > >]
Kaufman, Leonard [Vrije Universiteit Brussel - VUB > Department of Biostatistics (L.K.) > > >]
Gorus, F. K. mailto [Vrije Universiteit Brussel - VUB > Diabetes Research Center (I.W., B.K., F.C.S., B.V.D.A., M.R., P.D.P., F.K.G.) > > >]
Jun-2002
Journal of Clinical Endocrinology and Metabolism
Endocrine Soc
87
6
2597-2605
Yes
0021-972X
Bethesda
[en] We investigated inaugural disease phenotype in relation to the presence or absence of diabetes-associated autoantibodies and human leukocyte antigen (HLA) DQ risk genotypes in adult-onset diabetic patients. Blood samples and questionnaires were obtained from 1584 recent-onset Belgian Caucasian patients (age 15-39 yr at diagnosis of primary diabetes) who were recruited by the Belgian Diabetes Registry over an 11-yr period. At clinical diagnosis, antibody-positive patients (n = 1198) were on average younger and had more symptoms, a more acute disease onset, lower body mass index, and random C-peptide levels, but higher insulin needs, glycemia, and prevalence of ketonuria, HLA-DQ, and 5' insulin gene susceptibility genotypes (P < 0.001 vs. antibody-negative patients; n = 386). In antibody-positive patients, these characteristics did not differ according to HLA-DQ genotype. However, in antibody-negative subjects, we found that patients were younger (P = 0.001); had a lower body mass index (P < 0.001), higher insulin needs (P = 0.014), and amylasemia (P = 0.001); and tended to have a higher glycemia and lower C-peptide in the presence of susceptible HLA-DQ genotypes. Differences according to HLA-DQ genotype subsisted after careful age-matching. In conclusion, we found no relation between initial disease phenotype and HLA-DQ genotype in antibody-positive diabetic young adults. In contrast, antibody-negative patients displayed more type I-like features when carrying susceptible HLA-DQ genotypes known to promote the development of antibody-positive diabetes. The overrepresentation of these susceptibility genotypes in antibody-negative patients suggests the existence of an immune-mediated disease process with as yet unidentified immune markers in a subgroup of seronegative patients.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/6254
also: http://hdl.handle.net/2268/12187
http://www.mdconsult.com/das/article/body/112551287-4/jorg=journal&source=MI&sp=12408715&sid=779620611/N/288673/1.html?issn=0021-972X

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
The Impact of the Human Genome on Endocrinology_ocr.pdfNo commentaryAuthor postprint304.94 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.