Article (Scientific journals)
Maladie de Horton et atteintes arterielles extratemporales: utilite de la tomographie par emission de positons au 18FDG. A propos de trois observations et d'une revue de la litterature
Belhocine, Tarik; Kaye, Olivier; Delanaye, Pierre et al.
2002In Revue de Médecine Interne, 23 (7), p. 584-91
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Maladie de Horton et atteintes arterielles extratemporales utilite de la tomographie par emission de positons au 18FDG A propos de trois observations et d'une revue de .pdf
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Keywords :
Aged; giant cell arteritis; Horton's disease; Aorta/pathology; vasculitis; Carotid Arteries/pathology; positron emission tomography; Female; F-18-fluorodeoxyglucose; Fluorodeoxyglucose F18/diagnostic use; Giant Cell Arteritis/physiopathology/radionuclide imaging; Glucose/metabolism; Humans; Male; Middle Aged; Radiopharmaceuticals/diagnostic use; Subclavian Artery/pathology; Tomography, Emission-Computed
Abstract :
[en] PURPOSE: We report three cases of Horton's disease, in which F18-Fluorine-2-Deoxy-D-Glucose (18FDG) positron emission tomography (PET) demonstrated a clinically unsuspected extra-cranial vessels hypermetabolism. METHODS: Fully corrected whole-body PET was performed in three patients (two women, one man) for exploring a marked inflammatory syndrome. Scanning was acquired 60 min after i.v. injection of 222 MBq of 18FDG in average. RESULTS: In two patients with histologically proven Horton's disease, PET alone showed increased glucose metabolism involving the carotid and sub-clavian arteries as well as the ascending aorta, aortic arch, thoracic and abdominal aorta, and the iliac and femoral arteries. In the third patient, by detecting cervical, thoracic and abdominal vessel hypermetabolism, PET non-invasively contributed to the diagnosis of giant cell arteritis. All patients had complete clinical and biological response to corticoids. PET controls performed 3- to 6-months post-treatment, confirmed the disappearance of the metabolic stigma. CONCLUSION: 18FDG PET may show an increased glucose metabolism in asymptomatic extracranial vessels locations of Horton's arterities. If these observations are confirmed on controlled trials, PET could be particularly useful for non-invasive diagnosing, staging and monitoring atypical clinical forms of Horton's disease. The metabolic imaging could also contribute to a better understanding of the pathogenesis of GCA.
Disciplines :
Neurology
Author, co-author :
Belhocine, Tarik
Kaye, Olivier
Delanaye, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
Corman, Vincianne
Baghaie, M.
Deprez, Manuel ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Daenen, Frédéric ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
De Barsy, C.
Beckers, Catherine ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Gomez, P.
Hustinx, Roland  ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Foidart-Willems, Jacqueline ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Demonty, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale
Malaise, Michel ;  Centre Hospitalier Universitaire de Liège - CHU > Rhumatologie
Rigo, Pierre ;  Université de Liège - ULiège > Département des sciences de la motricité > Pathologie générale et médecine nucléaire
More authors (5 more) Less
Language :
French
Title :
Maladie de Horton et atteintes arterielles extratemporales: utilite de la tomographie par emission de positons au 18FDG. A propos de trois observations et d'une revue de la litterature
Alternative titles :
[en] Horton's disease and extra-temporal vessel locations: role of 18FDG PET scan. Report of 3 cases and review of the literature
Publication date :
2002
Journal title :
Revue de Médecine Interne
ISSN :
0248-8663
Publisher :
Elsevier, Paris, France
Volume :
23
Issue :
7
Pages :
584-91
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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