ORBi: Belhocine T. - Maladie de Horton et atteintes arterielles extratemporales: utilite de la tomographie par emission de positons au 18FDG. A propos de trois observations et d'une revue de la litterature

Reference : Maladie de Horton et atteintes arterielles extratemporales: utilite de la tomographie pa...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Neurology
	To cite this reference:	http://hdl.handle.net/2268/62381

Title :	Maladie de Horton et atteintes arterielles extratemporales: utilite de la tomographie par emission de positons au 18FDG. A propos de trois observations et d'une revue de la litterature
Language :	French
Alternative title :	[en] Horton's disease and extra-temporal vessel locations: role of 18FDG PET scan. Report of 3 cases and review of the literature
Author, co-author :	Belhocine, T. [> > > >]
	Kaye, O. [> >]
	Delanaye, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
	Corman, V. [> > > >]
	Baghaie, M. [> > > >]
	Deprez, Manuel [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
	Daenen, Frédéric [Centre Hospitalier Universitaire de Liège - CHU > > Médecine nucléaire >]
	De Barsy, C. [> > > >]
	Beckers, Catherine [Centre Hospitalier Universitaire de Liège - CHU > > Médecine nucléaire >]
	Gomez, P. [> > > >]
	Hustinx, Roland [Centre Hospitalier Universitaire de Liège - CHU > > Médecine nucléaire >]
	Foidart, Jacqueline [Centre Hospitalier Universitaire de Liège - CHU > > Médecine nucléaire >]
	Demonty, Jean [Centre Hospitalier Universitaire de Liège - CHU > > Maladies infectieuses et médecine interne générale >]
	Malaise, Michel [Centre Hospitalier Universitaire de Liège - CHU > > Rhumatologie >]
	Rigo, Pierre [Université de Liège - ULg > Département des sciences de la motricité > Pathologie générale et médecine nucléaire >]
Publication date :	2002
Journal title :	Revue de Médecine Interne
Publisher :	Elsevier
Volume :	23
Issue/season :	7
Pages :	584-91
Audience :	International
ISSN :	0248-8663
City :	Paris
Country :	France
Keywords :	[en] Aged ; Aorta/pathology ; Carotid Arteries/pathology ; Female ; Fluorodeoxyglucose F18/diagnostic use ; Giant Cell Arteritis/physiopathology/radionuclide imaging ; Glucose/metabolism ; Humans ; Male ; Middle Aged ; Radiopharmaceuticals/diagnostic use ; Subclavian Artery/pathology ; Tomography, Emission-Computed
Abstract :	[en] PURPOSE: We report three cases of Horton's disease, in which F18-Fluorine-2-Deoxy-D-Glucose (18FDG) positron emission tomography (PET) demonstrated a clinically unsuspected extra-cranial vessels hypermetabolism. METHODS: Fully corrected whole-body PET was performed in three patients (two women, one man) for exploring a marked inflammatory syndrome. Scanning was acquired 60 min after i.v. injection of 222 MBq of 18FDG in average. RESULTS: In two patients with histologically proven Horton's disease, PET alone showed increased glucose metabolism involving the carotid and sub-clavian arteries as well as the ascending aorta, aortic arch, thoracic and abdominal aorta, and the iliac and femoral arteries. In the third patient, by detecting cervical, thoracic and abdominal vessel hypermetabolism, PET non-invasively contributed to the diagnosis of giant cell arteritis. All patients had complete clinical and biological response to corticoids. PET controls performed 3- to 6-months post-treatment, confirmed the disappearance of the metabolic stigma. CONCLUSION: 18FDG PET may show an increased glucose metabolism in asymptomatic extracranial vessels locations of Horton's arterities. If these observations are confirmed on controlled trials, PET could be particularly useful for non-invasive diagnosing, staging and monitoring atypical clinical forms of Horton's disease. The metabolic imaging could also contribute to a better understanding of the pathogenesis of GCA.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/62381
Mentions required by the publisher for OA :	Must link to journal home page or articles' DOI http://www.elsevier.com/wps/find/homepage.cws_home Publisher's version/PDF cannot be used Articles in some journals can be made Open Access on payment of additional charge author can archive post-print (ie final draft post-refereeing)

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Open access	Maladie de Horton et atteintes arterielles extratemporales utilite de la tomographie par emission de positons au 18FDG A propos de trois observations et d'une revue de .pdf		Author postprint	905.59 kB	View/Open

All documents in ORBi are protected by a user license.

Dspace v1.5