Reference : MCI conversion to dementia and the APOE genotype : A prediction study with FDG-PET
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
http://hdl.handle.net/2268/62016
MCI conversion to dementia and the APOE genotype : A prediction study with FDG-PET
English
Mosconi, L. [> > > >]
Perani, D. [> > > >]
Sorbi, S. [> > > >]
Herholz, K. [> > > >]
Nacmias, B. [> > > >]
Holthoff, V. [> > > >]
Salmon, Eric mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Baron, J. C. [> > > >]
De Cristofaro, M. T. R. [> > > >]
Padovani, A. [> > > >]
Borroni, B. [> > > >]
Franceschi, M. [> > > >]
Bracco, L. [> > > >]
Pupi, A. [> > > >]
28-Dec-2004
Neurology
Lippincott Williams & Wilkins
63
12
2332-2340
Yes (verified by ORBi)
International
0028-3878
Philadelphia
[en] Objectives: To investigate whether the combination of fluoro-2-deoxy-D-glucose (FDG) PET measures with the APOE genotype would improve prediction of the conversion from mild cognitive impairment (MCI) to Alzheimer disease ( AD). Method: After 1 year, 8 of 37 patients with MCI converted to AD (22%). Differences in baseline regional glucose metabolic rate (rCMRglc) across groups were assessed on a voxel-based basis using a two-factor analysis of variance with outcome (converters [n = 8] vs nonconverters [n = 29]) and APOE genotype (E4 carriers [E4+] [n = 16] vs noncarriers [E4-] [n = 21]) as grouping factors. Results were considered significant at p < 0.05, corrected for multiple comparisons. Results: All converters showed reduced rCMRglc in the inferior parietal cortex (IPC) as compared with the nonconverters. Hypometabolism in AD-typical regions, that is, temporoparietal and posterior cingulate cortex, was found for the E4+ as compared with the E4- patients, with the E4+/converters (n = 5) having additional rCMRglc reductions within frontal areas, such as the anterior cingulate (ACC) and inferior frontal (IFC) cortex. For the whole MCI sample, IPC rCMRglc predicted conversion to AD with 84% overall diagnostic accuracy (p = 0.003). Moreover, ACC and IFC rCMRglc improved prediction for the E4+ group, yielding 100% sensitivity, 90% specificity, and 94% accuracy (p < 0.0005), thus leading to an excellent discrimination. Conclusion: Fluoro-2-deoxy-D-glucose-PET measures may improve prediction of the conversion to Alzheimer disease, especially in combination with the APOE genotype.
http://hdl.handle.net/2268/62016

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