ORBi: Schnitzler Joseph - Effects of persistent organic pollutants on the thyroid function of the sea bass (Dicentrarchus labrax), an endocrine disruption?

Reference : Effects of persistent organic pollutants on the thyroid function of the sea bass (Dicent...


	Document type :	Scientific congresses and symposiums : Unpublished conference
	Discipline(s) :	Life sciences : Environmental sciences & ecology Life sciences : Aquatic sciences & oceanology
	To cite this reference:	http://hdl.handle.net/2268/61988

Title :	Effects of persistent organic pollutants on the thyroid function of the sea bass (Dicentrarchus labrax), an endocrine disruption?
Language :	English
Author, co-author :	Schnitzler, Joseph [Université de Liège - ULg > Département des sciences et gestion de l'environnement > Océanologie >]
	Koutrakis, Emmanuil [ > > ]
	Thomé, Jean-Pierre [Université de Liège - ULg > Département des sciences et gestion de l'environnement > Ecologie animale et écotoxicologie >]
	Siebert, Ursula [ > > ]
	Das, Krishna [Université de Liège - ULg > Département des sciences et gestion de l'environnement > Océanologie >]
Publication date :	23-May-2007
Page number :	1
On invitation :	No
Audience :	International
Event name :	SETAC Europe 17th Annual Meeting
Event date :	20-24 May 2007
Event organizer :	Society of Environmental Toxicology and Chemistry
Event place (city) :	Porto
Event country :	Portugal
Keywords :	[en] Endocrine disruption ; thyroid ; seabass
Abstract :	[en] Organochlorinated compounds such as polychlorobiphenyls (PCB), dichloro-diphenyl-dichloroethylene (DDE) and dichloro-diphenyl-trichloroethane (DDT) have the characteristic to influence the endocrine system of many fish species and mammals and are thus qualified as endocrine disruptors. The objective of this project aims a better understanding of the effects of these compounds on the thyroid function of European seabass (Dicentrarchus labrax). Thyroid tissue and muscle of 46 seabass from the Aegean Sea in Greece (fished and aquaculture, n=15 and n=31, respectively) were sampled. The levels in PCBs, DDT and DDE were evaluated in the muscles of 30 individuals. The diameter of follicles and the epithelial cell heights were measured in each individual by optical microscopy. The concentration of the thyroid hormone T4 (thyroxin) was measured by Radio-Immuno-Assay (RIA). Finally, the potential relationships between these thyroid parameters and these organic compounds were investigated using factor analysis and multiple regressions. A significant relationship between persistent organic pollutants (muscular PCBs and DDT concentration) and the different thyroid parameters (diameters of follicles, epithelial cell heights and muscular T4 levels) could be observed. We cannot exclude the assumption that an endocrine disruption of thyroid gland related to these pollutants could be the origin of the modifications of these thyroid parameters.
Research units :	Centre Interfacultaire de Recherches en Océanologie - MARE
Funders :	Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA
Target :	Researchers ; Professionals ; Students ; General public
Permalink :	http://hdl.handle.net/2268/61988

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Open access	Schnitzler SETAC 2007.pdf		Publisher postprint	3.58 MB	View/Open

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