Article (Scientific journals)
The neural substrate of orientation working memory
Cornette, Luc; Dupont, Patrick; Salmon, Eric et al.
2001In Journal of Cognitive Neuroscience, 13 (6), p. 813-828
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Keywords :
neuroimaging; working memory
Abstract :
[en] We have used positron emission tomography (PET) to identify the neural substrate of two major cognitive components of working memory (WM), maintenance and manipulation of a single elementary visual attribute, i.e., the orientation of a grating presented in central vision. This approach allowed us to equate difficulty across tasks and prevented subjects from using verbal strategies or vestibular cues. Maintenance of orientations involved a distributed fronto-parietal network, that is, left and right lateral superior frontal sulcus (SFSl), bilateral ventrolateral prefrontal cortex (VLPFC), bilateral precuneus, and right superior parietal lobe (SPL). A more medial superior frontal sulcus region (SFSm) was identified as being instrumental in the manipulative operation of updating orientations retained in the WM. Functional connectivity analysis revealed that orientation WM relies on a coordinated interaction between frontal and parietal regions. In general, the current findings confirm the distinction between maintenance and manipulative processes, highlight the functional heterogeneity in the prefrontal cortex (PFC), and suggest a more dynamic view of WM as a process requiring the coordinated interaction of anatomically distinct brain areas.
Disciplines :
Neurology
Neurosciences & behavior
Author, co-author :
Cornette, Luc
Dupont, Patrick
Salmon, Eric  ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Orban, Guy
Language :
English
Title :
The neural substrate of orientation working memory
Publication date :
2001
Journal title :
Journal of Cognitive Neuroscience
ISSN :
0898-929X
eISSN :
1530-8898
Publisher :
M I T Press, Cambridge, United Kingdom
Volume :
13
Issue :
6
Pages :
813-828
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 June 2010

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