[en] We report a cognitive investigation of a case of deep dysphasia appearing in the context of primary progressive aphasia. Over a period of 5 years, patient CO presented progressive difficulties in word finding and in oral comprehension, while nonverbal cognitive functions remained preserved. As in other deep dysphasic patients, CO's repetition performance showed marked imageability and lexicality effects, and semantic paraphasias. The same effects were observed in writing-to-dictation. Regularisation errors occurred in word reading. CO's short-term memory span was less than two words. A cognitive analysis of language processing revealed difficulties in phoneme identification and rhyme judgement, in detecting grammatical class for orally presented words, and in oral and written naming. The interpretation of CO's deep dysphasic symptoms within interactive models of language processing confirmed the importance of a phonological short-term storage impairment as an explanatory factor of deep dysphasia.
Disciplines :
Neurology
Author, co-author :
Majerus, Steve ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Lekeu, Françoise ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Van der Linden, Martial ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Language :
English
Title :
Deep dysphasia : Further evidence on the relationship between phonological short-term memory and language processing impairments
Bachy N. (1987) Approche cognitive des troubles en dénomination de l'aphasie adulte. Création et étalonnage de deux batteries d'analyse., Unpublished doctoral dissertation, University of Louvain, Belgium.; .
Baddeley A.D., Emslie H., Nimmo-Smith I., The Doors and People Test. Bury St. Edmunds, UK: The Thames Valley Test Company.; 1994.
Baudot J. (1992) Fréquences d'utilisation des mots en français écrit contemporain., Montréal: Les Presses de l'Université de Montréal.; .
Black S. (1996) Focal cortical atrophy syndromes. Brain and Cognition 31:188-299.
Butterworth B., Warrington E. (1995) Two routes to repetition: Evidence from a case of deep dysphasia. Neurocase 1:55-66.
Cardebat D., Puel M., Démonet J.F., Nespoulous J.L. (1991) Les différentes "boîtes" de la répétition: Analyse d'un cas de dysphasie profonde. Revue de Neuropsychologie 1:215-232.
Corsi P.M. (1972) Human memory and the medial temporal region of the brain., Unpublished thesis, McGill University, Montréal, Canada.; .
Coslett H.B. (1991) Read but not write "idea": Evidence for a third reading mechanism. Brain and Language 40:425-443.
Coyette F., Van der Linden M. (1999) Elaboration et normalisation d'une épreuve de rappel libre/rappel indicé adaptée de la procédure de Grober et Buschke (1987)., and the members of the GRECO memory task force Manuscript in preparation, University of Louvain, Belgium.; .
Croot K., Patterson K., Hodges J.R. (1999) Familial progressive aphasia: Insights into the nature and deterioration of single word processing. Cognitive Neuropsychology 16:705-747.
Cummings J. (1997) The neuropsychiatric inventory: Assessing psychopathology in dementia patients. Neurology 48.
Dell G.S. (1986) A spreading-activation theory of retrieval in sentence production. Psychological Review 93:283-321.
De Partz M.P. (1994) L'approche clinique cognitive des dyslexies et des dysorthographies acquises., Unpublished doctoral dissertation, University of Louvain, Belgium.; .
De Partz M.P. (1995) Deficit of the graphemic buffer: Effects of a written lexical segmentation strategy. Neuropsychological Rehabilitation 5:129-147.
Duhamel J.R., Poncet M. (1986) Deep dysphasia in a case of phonemic deafness: Role of the right hemisphere in auditory language comprehension. Neuropsychologia 24:769-779.
Franklin S., Howard D., Patterson K. (1994) Abstract word meaning deafness. Cognitive Neuropsychology 11:1-34.
Franklin S., Turner J.E., Ellis A.W., The ADA Comprehension Battery. York, UK: University of York Human Neuropsychology Laboratory.; 1992.
Friston K., Holmes A., Worsley K.J., Poline J.B., Frith C., Frackowiak R. (1995) Statistical parametric maps in functional imaging: A general approach. Human Brain Mapping 2:189-210.
Goldblum M.C. (1980) Auditory analogue of deep dysplexia. Experimental Brain Research, Supplement II: Hearing and Speech 397-405.
Grober E., Buschke H. (1987) Genuine memory deficits in dementia. Developmental Psychology 3:13-36.
Hogenraad R., Orianne E. (1981) Valences d'imagerie de 1130 noms de la langue française parlée. Psychologica Belgica 11:21-30.
Howard D., Franklin S. (1988) Missing the meaning? A cognitive neuropsychological study of the processing of words by an aphasic patient., Cambridge, MA: MIT Press.; .
Howard D., Franklin S. (1990) Memory without rehearsal. Neuropsychological Impairments of STM , G. Vallar & T. Shallice (Eds.), Cambridge: Cambridge University Press.; 287-318.
Howard D., Patterson K.E., The Pyramids and Palm Trees Test: A test of semantic access from words and pictures. Bury St. Edmunds, UK: The Thames Valley Test Company.; 1992.
Katz R., Goodglass H. (1990) Deep dysphasia: An analysis of a rare form of repetition disorder. Brain and Language 39:153-185.
Kopelman M.D., Wilson B.A., Baddeley A.D., The autobiographical memory interview. Bury St. Edmunds, UK: The Thames Valley Test Company.; 1990.
Lawton M.P., Brody E.M. (1969) Assessment of older people: Self-maintaining and instrumental activities of daily living. Gerontologist 9:179-186.
Luria A.R., Higher cortical functions in man. New York: Basic Books.; 1966.
Marshall J.C., Newcombe F. (1988) Parasyndromes and paragrammatism. Aphasiology 2:337-342.
Martin N. (1996) Models of deep dysphasia. Neurocase 2:73-80.
Martin N., Dell G.S., Saffran E.M., Schwartz M.F. (1994) Origins of paraphasias in deep dysphasia: Testing the consequences of a decay impairment to an interactive spreading activation model of lexical retrieval. Brain and Language 47:609-660.
Martin N., Saffran E. (1992) A computational account of deep dysphasia: Evidence from a single case study. Brain and Language 43:240-274.
Martin N., Saffran E. (1997) Language and auditory-verbal STM impairments: Evidence for common underlying processes. Cognitive Neuropsychology 14:641-682.
Martin N., Saffran E.M., Dell G.S. (1996) Recovery in deep dysphasia: Evidence for a relation between auditory-verbal STM capacity and lexical errors in repetition. Brain and Language 52:83-113.
Martin R.C., Lesch M.F., Bartha M.C. (1999) Independence of input and output phonology in word processing and STM. Journal of Memory and Language 41:3-29.
Martin R.C., Shelton J.R., Yaffee L.S. (1994) Language processing and working memory: Neuropsychological evidence for separate phonological and semantic capacities. Journal of Memory and Language 33:83-111.
Mattis S. (1976) Mental status examination for organic mental syndrome in the elderly patient. Geriatric Psychiatry , L. Bellak & T.E. Karasu (Eds.), New York: Grune & Stratton.; 77-121.
Mesulam M.M. (1982) Slowly progressive aphasia without generalised dementia. Annals of Neurology 11:592-598.
Mesulam M.M. (1987) Primary progressive aphasia - Differentiation from Alzheimer's disease. Annals of Neurology 22:532-534.
Metz-Lutz M.N., Dahl E. (1984) Analysis of word comprehension in a case of pure word deafness. Brain and Language 23:13-25.
Meulemans T. (1997) Span et supra-span visuels., Unpublished test, University of Liège, Belgium.; .
Michel F. (1979) Préservation du langage écrit malgré un déficit majeur du langage oral (à propos d'un cas clinique). Lyon Médical 241:141-149.
Michel F., Andreewsky E. (1983) Deep dysphasia: An analogue of deep dyslexia in the auditory modality. Brain and Language 18:212-223.
Morais J., Alegria J., Content A. (1987) The relationships between segmental analysis and alphabetical literacy: An interactive view. Cahiers de Psychologie Cognitive 7:462-464.
Morton J. (1980) Two auditory parallels to deep dyslexia. Deep Dyslexia, M. Coltheart, K.E. Patterson, & J.C. Marshall (Eds.), London: Routledge & Kegan Paul.; .
Nolan K.A., Caramazza A. (1982) Modality-independent impairments in word processing in a deep dyslexic patient. Brain and Language 16:237-264.
Pasquier F. (1999) Early diagnosis of dementia: Neuropsychology. Journal of Neurology 246:6-15.
Patterson K.E., Suzuki T., Wydell T., Sasanuma S. (1995) Progressive aphasia and surface alexia in Japanese. Neurocase 1:155-165.
Peigneux P., Van der Linden M. (1997) Batterie liégeoise d'évaluation des apraxies., Unpublished test, University of Liège, Belgium.; .
Phelps M.E., Huang S.E., Hoffman E.J. (1979) Tomographic measurement of local cerebral metabolic rate in humans with (F-18)-2-fluoro-2-deoxyglucose: Validation of method. Archives of Neurology 6:371-388.
Pondant S., Schwab A. (1996) Spoken-word-to-picture matching test., Unpublished test, University of Liège, Belgium.; .
Reitan R.M. (1958) Validity of trail making test as an indicator of organic brain damage. Perceptual and Motor Skills 8:271-276.
Rey A., Test de copie d'une figure complexe. Paris, France: Les Editions du Centre de Psychologie Appliquée.; 1959.
Shallice T. (1987) Impairments of semantic processing: Multiple dissociations. The Cognitive Neuropsychology of Language Hove , M. Coltheart, G. Sartori, & R. Job (Eds.), UK: Lawrence Erlbaum Associates Ltd.; 111-127.
Snowden J., Neary D. (1993) Progressive language dysfunction and lobar atrophy. Dementia 4:226-231.
Stroop J.R. (1935) Studies of interference in serial verbal reactions. Journal of Experimental Psychology 18:643-662.
(1998) Language assessment battery., The Members of the Language Rehabilitation Task Force Unpublished test, University of Liège and University of Louvain, Belgium.; .
Trojano L., Stanzione M., Grossi D. (1992) STM and verbal learning with auditory phonological coding defect: A neuropsychological case study. Brain and Cognition 18:12-33.
Valdois S., Carbonnel S., David D., Rousset S., Pellat J. (1995) Confrontation of PDP models and dual-route models through the analysis of a case of deep dysphasia. Cognitive Neuropsychology 12:681-724.
Weintraub S., Rubin N., Mesulam M. (1990) Primary progressive aphasia: Longitudinal course, neuropsychological profile, and language features. Archives of Neurology 47:1329-1335.
Wechsler D., Echelle d'Intelligence de Wechsler pour adultes - forme révisée. Paris: Les Editions du Centre de Psychologie Appliquée.; 1989.
Westbury C., Bub D. (1997) Primary progressive aphasia: A review of 112 cases. Brain and Language 60:381-406.