ORBi: Kalbe E. - Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairment

Reference : Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairment


	Document type :	Scientific journals : Article
	Discipline(s) :	Social & behavioral sciences, psychology : Sociology & social sciences Human health sciences : Neurology
	To cite this reference:	http://hdl.handle.net/2268/61949

Title :	Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairment
Language :	English
Author, co-author :	Kalbe, E. [> > > >]
	Salmon, Eric [Université de Liège - ULg > Centre de Recherches du Cyclotron - Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. > > >]
	Perani, D. [> > > >]
	Holthoff, V. [> > > >]
	Sorbi, S. [> > > >]
	Elsner, A. [> > > >]
	Weisenbach, S. [> > > >]
	Brand, M. [> > > >]
	Lenz, O. [> > > >]
	Kessler, J. [> > > >]
	Luedecke, S. [> > > >]
	Ortelli, P. [> > > >]
	Herholz, K. [> > > >]
Publication date :	2005
Journal title :	Dementia & Geriatric Cognitive Disorders
Publisher :	S. Karger
Volume :	19
Issue/season :	5-6
Pages :	349-356
Audience :	International
ISSN :	1420-8008
e-ISSN :	1421-9824
Keywords :	[en] anosognosia ; self awareness ; insight ; dementia ; cognitive dysfunction ; Alzheimer's disease ; mild cognitive impairment
Abstract :	[en] Objective: To study awareness of cognitive dysfunction in patients with very mild Alzheimer's disease (AD) and subjects with mild cognitive impairment (MCI). Methods: A complaint interview covering 13 cognitive domains was administered to 82 AD and 79 MCI patients and their caregivers. The patient groups were comparable according to age and education, and Mini Mental State Examination (MMSE) scores were ≥ 24 in all cases. The discrepancy between the patients' and caregivers' estimations of impairments was taken as a measure of anosognosia. Results: Self-reports of cognitive difficulties were comparable for AD and MCI patients. However, while in comparison to caregivers MCI patients reported significantly more cognitive impairment (p < 0.05), AD patients complained significantly less cognitive dysfunctions (p < 0.001). Conclusions: While most MCI patients tend to overestimate cognitive deficits when compared to their caregiver's assessment, AD patients in early stages of disease underestimate cognitive dysfunctions. Anosognosia can thus be regarded as a characteristic symptom at a stage of very mild AD (MMSE ≥ 24) but not MCI. Accordingly, medical history even in mildly affected patients should always include information from both patient and caregiver. Copyright (C) 2005 S. Karger AG, Basel.
Permalink :	http://hdl.handle.net/2268/61949

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