Reference : Impairment of neocortical metabolism predicts progression in Alzheimer's disease
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
http://hdl.handle.net/2268/61938
Impairment of neocortical metabolism predicts progression in Alzheimer's disease
English
Herholz, K. [> > > >]
Nordberg, A. [> > > >]
Salmon, Eric mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Perani, D. [> > > >]
Kessler, J. [> > > >]
Mielke, R. [> > > >]
Halber, M. [> > > >]
Jelic, V. [> > > >]
Almkvist, O. [> > > >]
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie >]
Alberoni, M. [> > > >]
Kennedy, A. [> > > >]
Hasselbalch, S. [> > > >]
Fazio, F. [> > > >]
Heiss, W.-D. [> > > >]
1999
Dementia & Geriatric Cognitive Disorders
S. Karger
10
6
494-504
Yes (verified by ORBi)
International
1420-8008
[de] Ka-ALZHEIMER'S DISEASE ; Ka-CEREBRAL GLUCOSE METABOLISM ; Ka-EMISSION COMPUTED TOMOGRAPHY ; Ka-MULTICENTER STUDY ; Ka-PROSPECTIVE STUDY
[en] Studied prediction of progression rates of Alzheimer's disease (AD) in a prospective multicenter cohort study of 186 patients (mean age 63.2 yrs) with possible or probable AD, mostly with presenile onset. In a cross-sectional analysis at entry, impairment of glucose metabolism in temporoparietal or frontal association areas measured with positron emission tomography was significantly associated with dementia severity, clinical classification as possible vs probable AD, presence of multiple cognitive deficits and history of progression. A prospective longitudinal analysis showed a significant association between initial metabolic impairment and subsequent clinical deterioration. In patients with mild cognitive deficits at entry, the risk of deterioration was up to 4.7 times higher if the metabolism was severely impaired than with mild or absent metabolic impairment.
http://hdl.handle.net/2268/61938

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