[en] We report neuropsychological and neuroimaging investigations performed in a patient suffering from presenile onset degenerative dementia and subsequent mild extrapyramidal and pyramidal signs. Early neuropsychological testing revealed frontal lobe dysfunction. Neuroanatomical pictures were not contributive. After four years of evolution, the clinical pattern was consistent with progressive supranuclear palsy. Statistical parametric mapping analysis of functional imaging revealed a highly significant metabolic impairment in the anterior cingulate gyrus, that might be a key feature of subcortico-frontal dementia in progressive supranuclear palsy.
Disciplines :
Neurology
Author, co-author :
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Meulemans, Thierry ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Van der Linden, Martial ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Degueldre, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Franck, Georges ; Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Anterior cingulate dysfunction in presenile dementia due to progressive supranuclear palsy
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