No full text
Article (Scientific journals)
Postencephalitic stereotyped involuntary movements responsive to L-Dopa
Picard, F.; deSaintMartin, A.; Salmon, Eric et al.
1996In Movement Disorders, 11 (5), p. 567-570
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Encephalitis lethargica; Parkinsonism; Hyperkinesia; L-Dopa
Abstract :
[en] In 1954, at the age of 5 years, our patient had an encephalitic syndrome associated with a prolonged lethargic state. After this episode, he developed a severe parkinsonian syndrome that, after a few years, was associated with axial dystonia and stereotyped abnormal movements of the upper limbs. This complex and progressive extrapyramidal syndrome had many similarities to the encephalitis lethargica as described by von Economo. Results of cerebral computed tomography and magnetic resonance imaging were normal. Fluorodopa positron emission tomography showed a significant bilateral reduction of tracer accumulation in both putamen, similar to that observed in patients with idiopathic Parkinson's disease. However, in this patient, treatment with L-Dopa suppressed all akinetic, dystonic and dyskinetic symptoms. The effectiveness of L-Dopa was abolished by administration of a D2 antagonist and was fully reproduced by a D2 agonist. In conclusion, this patient presented a complex postencephalitic, extrapyramidal syndrome, with akinetic symptoms and involuntary movements. These symptoms appeared to be related to a limited lesion of the dopaminergic neurons of the zona compacta of the substantia nigra.
Disciplines :
Neurosciences & behavior
Neurology
Author, co-author :
Picard, F.
deSaintMartin, A.
Salmon, Eric  ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Hirsch, E.
Marescaux, C.
Language :
English
Title :
Postencephalitic stereotyped involuntary movements responsive to L-Dopa
Publication date :
1996
Journal title :
Movement Disorders
ISSN :
0885-3185
eISSN :
1531-8257
Publisher :
John Wiley & Sons
Volume :
11
Issue :
5
Pages :
567-570
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 June 2010

Statistics


Number of views
51 (4 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
17
Scopus citations®
without self-citations
17
OpenCitations
 
9

Bibliography


Similar publications



Contact ORBi