|Reference : Differential Diagnosis of Alzheimer's Disease with Pet|
|Scientific journals : Article|
|Human health sciences : Neurology|
|Differential Diagnosis of Alzheimer's Disease with Pet|
|Salmon, Eric [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]|
|Sadzot, Bernard [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques]|
|Maquet, Pierre [Université de Liège - ULg > > Centre de recherches du cyclotron]|
|Degueldre, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]|
|Bozet, Claire [Centre Hospitalier Universitaire de Liège - CHU > > O.R.L. >]|
|Rigo, Pierre [Université de Liège - ULg > Département des sciences de la motricité > Pathologie générale et médecine nucléaire >]|
|Comar, D. [> > > >]|
|Franck, Georges [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]|
|Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine|
|[en] PET studies have demonstrated bilateral temporo-parietal hypoperfusion and hypometabolism in probable and definite Alzheimer's disease (AD), a pattern that may help differentiate AD from other dementias. METHODS: To evaluate the diagnostic power of cerebral metabolic distribution patterns for "cortical" degenerative dementias, PET scans obtained from 129 patients referred for differential diagnosis of dementia were analyzed visually. RESULTS: Sixty-five patients had a final clinical diagnosis of probable AD. Ninety-seven percent (97%) of those had abnormal metabolic scans and 94% showed a suggestive pattern of bilateral or unilateral temporo-parietal hypometabolism (with or without frontal involvement). Hypometabolism was unilateral in 23% of patients. Five subjects with a neuropathologically proven diagnosis of Alzheimer's disease had a suggestive metabolic pattern. One of those was an early case with frontal hypometabolism exceeding temporo-parietal involvement. Two patients with Alzheimer's-type dementia had isolated bilateral frontal hypometabolism. CONCLUSIONS: This alternative metabolic pattern may correspond to a non-Alzheimer pathology occurring in 10%-20% of patients suffering from clinically probable Alzheimer's disease. Most of the patients with possible but atypical Alzheimer's-type dementia showed isolated bilateral frontal involvement. This metabolic pattern probably corresponds to different diseases, such as Pick's disease, frontal lobe dementia or progressive subcortical gliosis.|
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