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Differential diagnosis of Alzheimer's disease with PET.
Salmon, Eric; Sadzot, Bernard; Maquet, Pierre et al.
1994In Journal of Nuclear Medicine, 35 (3), p. 391-8
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Keywords :
Alzheimer Disease/radionuclide imaging; Brain/metabolism/radionuclide imaging; Dementia/radionuclide imaging; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Sensitivity and Specificity; Tomography, Emission-Computed
Abstract :
[en] PET studies have demonstrated bilateral temporo-parietal hypoperfusion and hypometabolism in probable and definite Alzheimer's disease (AD), a pattern that may help differentiate AD from other dementias. METHODS: To evaluate the diagnostic power of cerebral metabolic distribution patterns for "cortical" degenerative dementias, PET scans obtained from 129 patients referred for differential diagnosis of dementia were analyzed visually. RESULTS: Sixty-five patients had a final clinical diagnosis of probable AD. Ninety-seven percent (97%) of those had abnormal metabolic scans and 94% showed a suggestive pattern of bilateral or unilateral temporo-parietal hypometabolism (with or without frontal involvement). Hypometabolism was unilateral in 23% of patients. Five subjects with a neuropathologically proven diagnosis of Alzheimer's disease had a suggestive metabolic pattern. One of those was an early case with frontal hypometabolism exceeding temporo-parietal involvement. Two patients with Alzheimer's-type dementia had isolated bilateral frontal hypometabolism. CONCLUSIONS: This alternative metabolic pattern may correspond to a non-Alzheimer pathology occurring in 10%-20% of patients suffering from clinically probable Alzheimer's disease. Most of the patients with possible but atypical Alzheimer's-type dementia showed isolated bilateral frontal involvement. This metabolic pattern probably corresponds to different diseases, such as Pick's disease, frontal lobe dementia or progressive subcortical gliosis.
Disciplines :
Neurology
Author, co-author :
Salmon, Eric  ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Sadzot, Bernard ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Degueldre, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Lemaire, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Rigo, Pierre ;  Université de Liège - ULiège > Département des sciences de la motricité > Département des sciences de la motricité
Comar, D.
Franck, Georges ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Differential diagnosis of Alzheimer's disease with PET.
Publication date :
1994
Journal title :
Journal of Nuclear Medicine
ISSN :
0161-5505
eISSN :
1535-5667
Publisher :
Kexue Chubaneshe/Science Press, China
Volume :
35
Issue :
3
Pages :
391-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 June 2010

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