Reference : Differential diagnosis of Alzheimer's disease with PET.
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/61934
Differential diagnosis of Alzheimer's disease with PET.
English
Salmon, Eric mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Sadzot, Bernard mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Maquet, Pierre mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Lemaire, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Rigo, Pierre mailto [Université de Liège - ULg > Département des sciences de la motricité > Département des sciences de la motricité >]
Comar, D. [> >]
Franck, Georges [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]
1994
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
35
3
391-8
Yes (verified by ORBi)
International
0161-5505
1535-5667
UNITED STATES
[en] Alzheimer Disease/radionuclide imaging ; Brain/metabolism/radionuclide imaging ; Dementia/radionuclide imaging ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Sensitivity and Specificity ; Tomography, Emission-Computed
[en] PET studies have demonstrated bilateral temporo-parietal hypoperfusion and hypometabolism in probable and definite Alzheimer's disease (AD), a pattern that may help differentiate AD from other dementias. METHODS: To evaluate the diagnostic power of cerebral metabolic distribution patterns for "cortical" degenerative dementias, PET scans obtained from 129 patients referred for differential diagnosis of dementia were analyzed visually. RESULTS: Sixty-five patients had a final clinical diagnosis of probable AD. Ninety-seven percent (97%) of those had abnormal metabolic scans and 94% showed a suggestive pattern of bilateral or unilateral temporo-parietal hypometabolism (with or without frontal involvement). Hypometabolism was unilateral in 23% of patients. Five subjects with a neuropathologically proven diagnosis of Alzheimer's disease had a suggestive metabolic pattern. One of those was an early case with frontal hypometabolism exceeding temporo-parietal involvement. Two patients with Alzheimer's-type dementia had isolated bilateral frontal hypometabolism. CONCLUSIONS: This alternative metabolic pattern may correspond to a non-Alzheimer pathology occurring in 10%-20% of patients suffering from clinically probable Alzheimer's disease. Most of the patients with possible but atypical Alzheimer's-type dementia showed isolated bilateral frontal involvement. This metabolic pattern probably corresponds to different diseases, such as Pick's disease, frontal lobe dementia or progressive subcortical gliosis.
http://hdl.handle.net/2268/61934
also: http://hdl.handle.net/2268/126984

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