Reference : Comparison between single-beat and multiple-beat methods for estimation of right ventric...
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/61911
Comparison between single-beat and multiple-beat methods for estimation of right ventricular contractility.
English
Lambermont, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Segers, Patrick [> > > >]
Ghuysen, Alexandre mailto [Université de Liège - ULg > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière >]
Tchana-Sato, Vincent [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
Morimont, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Dogné, Jean-Michel [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Kolh, Philippe mailto [Université de Liège - ULg > Département des Sciences biomédicales et précliniques > Service de biochimie et de physiologie humaines, normales et pathologiques > >]
Gérard, Paul mailto [Université de Liège - ULg > Département de mathématique > Statistique mathématique >]
D'Orio, Vincenzo mailto [Université de Liège - ULg > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path. >]
2004
Critical Care Medicine
Lippincott Williams & Wilkins
32
9
1886-90
Yes (verified by ORBi)
International
0090-3493
1530-0293
Philadelphia
PA
[en] Animals ; Cardiotonic Agents/diagnostic use ; Dobutamine/diagnostic use ; Heart Catheterization ; Heart Function Tests/methods ; Hemodynamics/physiology ; Myocardial Contraction/physiology ; Prospective Studies ; Swine ; Ventricular Function, Right/physiology
[en] OBJECTIVE: It was investigated whether pharmacologically induced changes in right ventricular contractility can be detected by a so-called "single-beat" method that does not require preload reduction. DESIGN: Prospective animal research. SETTING: Laboratory at a large university medical center. SUBJECTS: Eight anesthetized pigs. INTERVENTIONS: End-systolic elastance values obtained by a recently proposed single-beat method (Eessb) were compared with those obtained using the reference multiple-beat method (Eesmb). MEASUREMENTS AND MAIN RESULTS: Administration of dobutamine increased Eesmb from 1.6 +/- 0.3 to 3.8 +/- 0.5 mm Hg/mL (p =.001), whereas there was only a trend toward an increase in Eessb from 1.5 +/- 0.2 to 1.7 +/- 0.4 mm Hg/mL. Esmolol decreased Eesmb from 1.7 +/- 0.3 to 1.1 +/- 0.2 mm Hg/mL (p =.006), whereas there was only a trend for a decrease in Eessb from 1.5 +/- 0.2 to 1.3 +/- 0.1. CONCLUSIONS: The present method using single-beat estimation to assess right ventricular contractility does not work as expected, since it failed to detect either increases or decreases in right ventricular contractility induced by pharmacologic interventions.
http://hdl.handle.net/2268/61911
also: http://hdl.handle.net/2268/89876
http://www.ccmjournal.com/

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