ORBi: Detry Olivier - Oxidative stress in the liver and the brain of rats in fulminant hepatic failure

Reference : Oxidative stress in the liver and the brain of rats in fulminant hepatic failure


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Gastroenterology & hepatology Human health sciences : Anesthesia & intensive care Human health sciences : Surgery Human health sciences : Neurology
	To cite this reference:	http://hdl.handle.net/2268/618

Title :	Oxidative stress in the liver and the brain of rats in fulminant hepatic failure
Language :	English
Author, co-author :	Detry, Olivier [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	Gaspar, Yves [ > > ]
	Cheramy-Bien, Jean-Paul [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
	De Roover, Arnaud [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	Honore, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	Meurisse, Michel [Université de Liège - ULg > Département des sciences cliniques > Chirurgicale abdominale]
	Defraigne, Jean-Olivier [Université de Liège > Département des sciences biomédicales et précliniques > Biochimie générale, bioch. et path. humaine et pathologiques >]
	Pincemail, Joël [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
Publication date :	2005
Journal title :	Transplantation Proceedings
Publisher :	Elsevier Science Inc
Volume :	37
Issue/season :	6, Jul-Aug
Pages :	2883-2885
Audience :	International
ISSN :	0041-1345
City :	New York
Keywords :	[en] brain ; brain edema ; ooxidative stress
	[fr] liver failure ; physiopathology
Abstract :	[en] The etiological mechanisms of brain edema in fulminant hepatic failure are incompletely understood. In a surgical model of fulminant hepatic failure in the rat, we tested whether oxidative stress may be involved in the early steps of brain edema. Moreover, we took advantage of this model to determine if oxidative stress may be involved in the hepatocyte dysfunction observed in the setting of fulminant hepatic failure. Oxidative stress was evaluated by measurement of tissue ascorbic acid in the brain and liver of rats at 6 hours after induction of fulminant hepatic failure versus in control or partially hepatectomized rats. After 6 hours, the level of ascorbic acid was not different in the brain tissue of the various groups, indicating no oxidative stress. The liver showed a significant decrease in ascorbic acid levels, both in ischemic and nonischemic liver tissue, suggesting that oxidative stress might be involved in the failure of liver regeneration in fulminant hepatic failure. In this rat model no oxidative stress was demonstrated in the brain during the early phase of fulminant liver failure.
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/618
DOI :	10.1016/j.transproceed.2005.05.012

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