Reference : Oxidative stress in the liver and the brain of rats in fulminant hepatic failure
Scientific journals : Article
Human health sciences : Gastroenterology & hepatology
Human health sciences : Anesthesia & intensive care
Human health sciences : Surgery
Human health sciences : Neurology
http://hdl.handle.net/2268/618
Oxidative stress in the liver and the brain of rats in fulminant hepatic failure
English
Detry, Olivier mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Gaspar, Yves [ > > ]
Cheramy-Bien, Jean-Paul mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
De Roover, Arnaud mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Honore, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Meurisse, Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Chirurgicale abdominale]
Defraigne, Jean-Olivier mailto [Université de Liège > Département des sciences biomédicales et précliniques > Biochimie générale, bioch. et path. humaine et pathologiques >]
Pincemail, Joël mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
2005
Transplantation Proceedings
Elsevier Science Inc
37
6, Jul-Aug
2883-2885
Yes (verified by ORBi)
International
0041-1345
New York
[en] brain ; brain edema ; ooxidative stress
[fr] liver failure ; physiopathology
[en] The etiological mechanisms of brain edema in fulminant hepatic failure are incompletely understood. In a surgical model of fulminant hepatic failure in the rat, we tested whether oxidative stress may be involved in the early steps of brain edema. Moreover, we took advantage of this model to determine if oxidative stress may be involved in the hepatocyte dysfunction observed in the setting of fulminant hepatic failure. Oxidative stress was evaluated by measurement of tissue ascorbic acid in the brain and liver of rats at 6 hours after induction of fulminant hepatic failure versus in control or partially hepatectomized rats. After 6 hours, the level of ascorbic acid was not different in the brain tissue of the various groups, indicating no oxidative stress. The liver showed a significant decrease in ascorbic acid levels, both in ischemic and nonischemic liver tissue, suggesting that oxidative stress might be involved in the failure of liver regeneration in fulminant hepatic failure. In this rat model no oxidative stress was demonstrated in the brain during the early phase of fulminant liver failure.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/618
10.1016/j.transproceed.2005.05.012

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