Article (Scientific journals)
Cyclosporin C Is the Main Antifungal Compound Produced by Acremonium Luzulae
Moussaif, M.; Jacques, Philippe; Schaarwachter, P. et al.
1997In Applied and Environmental Microbiology, 63 (5), p. 1739-43
Peer Reviewed verified by ORBi
 

Files


Full Text
Moussaif Appl env microbio 1997.pdf
Publisher postprint (242.87 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] A strain of Acremonium luzulae (Fuckel) W. Gams was selected in screening new microorganisms for biological control of fruit postharvest diseases, especially gray and blue mold diseases on apples and strawberries. This strain manifests a very strong activity against a large number of phytopathogenic fungi. In this work, the product responsible for this antifungal activity was isolated from modified Sabouraud dextrose broth cultures of A. luzulae. It was purified to homogeneity by reverse-phase column chromatography. On the basis of UV, infrared, and 1H and 13C nuclear magnetic resonance spectra, mass spectral analysis, and the amino acid composition of the acid hydrolysates, the antibiotic was determined to be cyclosporin C. Cyclosporin C showed a broad-spectrum activity against filamentous phytopathogenic fungi but no activity against bacteria or yeasts. Its antifungal activity is only fungistatic. In contrast to Tolypocladium inflatum, another cyclosporin-producing strain, A. luzulae, did not produce additional cyclosporins. This was confirmed by in vivo-directed biosynthesis.
Disciplines :
Microbiology
Author, co-author :
Moussaif, M.
Jacques, Philippe ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Bio-industries
Schaarwachter, P.
Budzikiewicz, H.
Thonart, Philippe ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech - Biochimie et microbiologie industrielles
Language :
English
Title :
Cyclosporin C Is the Main Antifungal Compound Produced by Acremonium Luzulae
Publication date :
May 1997
Journal title :
Applied and Environmental Microbiology
ISSN :
0099-2240
eISSN :
1098-5336
Publisher :
American Society for Microbiology, Washington, United States - District of Columbia
Volume :
63
Issue :
5
Pages :
1739-43
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 January 2010

Statistics


Number of views
86 (1 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
27
Scopus citations®
without self-citations
27
OpenCitations
 
25

Bibliography


Similar publications



Contact ORBi