Article (Scientific journals)
In vitro and in vivo analysis of macroporous biodegradable poly(D,L-lactide-co-glycolide) scaffolds containing bioactive glass
Day, Richard M; Maquet, Véronique; Boccaccini, Aldo R. et al.
2005In Journal of Biomedical Materials Research. Part A, 75A (4), p. 778-787
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Keywords :
biomaterial; scaffold
Abstract :
[en] Recent studies have demonstrated the angiogenic potential of 45S5 Bioglass (R). However, it is not known whether the angiogenic properties of Bioglass (R) remain when the bioactive glass particles are incorporated into polymer composites. The objectives of the current study were to investigate the angiogenic properties of 45S5 Bioglass (R) particles incorporated into biodegradable polymer composites. In vitro studies demonstrated that fibroblasts Cultured on discs consisting of specific quantities of Bioglass (R) particles mixed into poly(D,L-lactide-co-glycolide) secreted significantly increased quantities of vascular endothelial growth factor. The optimal quantity of Bioglass (R) particles determined from the in vitro experiments was incorporated into three-dimensional macroporous poly(D,L-lactide-co-glycolide) foam scaffolds. The foam scaffolds were fabricated using either compression molding or thermally induced phase separation processes. The foams were implanted subcutaneously into mice for periods Of Lip to 6 weeks. Histological assessment was used to determine the area of granulation tissue around the foams, and the number of blood vessels within the granulation tissue was counted. The presence of Bioglass (R) particles in the foams produced a sustained increase in the area of granulation tissue surrounding the foams. The number of blood vessels surrounding the neat foams was reduced after 2 weeks of implantation; however, compression-molded foams containing Bioglass (R) after 4 and 6 weeks of implantation had significant]), more blood vessels surrounding the foams compared with foams containing no Bioglass (R) at the same time points. These results indicate that composite polymer foam scaffolds containing Bioglass (R) particles retain granulation tissue and blood vessels surrounding the implanted foams. The use of this polymer composite for tissue engineering scaffolds might provide a novel approach for ensuring adequate vascular Supply to the implanted device.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Day, Richard M;  Burdett Institute of Gastrointestinal Nursing, King’s College, London, St. Mark’s Hospital, Harrow, UK > Biomaterials and Tissue Engineering Group
Maquet, Véronique;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Boccaccini, Aldo R.;  Imperial College, London, UK > Department of Materials and Centre for Tissue Engineering
Jérôme, Robert ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Forbes, Alastair;  Imperial College, London, UK > Faculty of Medicine
Language :
English
Title :
In vitro and in vivo analysis of macroporous biodegradable poly(D,L-lactide-co-glycolide) scaffolds containing bioactive glass
Publication date :
15 December 2005
Journal title :
Journal of Biomedical Materials Research. Part A
ISSN :
1549-3296
eISSN :
1552-4965
Publisher :
Wiley Liss, Inc., Hoboken, United States - New Jersey
Volume :
75A
Issue :
4
Pages :
778-787
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
The Medical Research Council Discipline Hopper Award scheme, the Kati Jacobs Appeal, and Rosetrees (T. R. Golden Trust)
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