Reference : Hyperacute graft rejection during heart transplantation for giant cell myocarditis: A ca...
Scientific journals : Article
Human health sciences : Surgery
http://hdl.handle.net/2268/61547
Hyperacute graft rejection during heart transplantation for giant cell myocarditis: A case report.
English
Mutijima, E. [> > > >]
Delbecque, Katty [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
Defraigne, Jean-Olivier mailto [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]
Bouillenne, C. [> > > >]
Damas, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
Pierard, Luc [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
Boniver, Jacques [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
de Leval, Laurence mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques - Département des sciences biomédicales et précliniques >]
2010
Pathology - Research & Practice
Gustav Fischer Verlag
15
206
411-4
Yes (verified by ORBi)
International
0344-0338
Stuttgart
Germany
[en] We report the case of a patient with giant cell myocarditis who was bridged to transplantation with mechanical circulatory support and developed a fatal perioperative hyperacute rejection. The patient had received abundant transfusions that had raised her anti-HLA antibody titers. The cross-match test was positive. No pre-transplantation immunosuppressive therapy had been administered given concomitant infection. The severity and acuteness of the rejection in this case likely reflect the combined effect of preformed anti-HLA antibodies in the context of an active organ-specific immune process at the time of transplantation. This case raises the questions of the need for intensive immunosuppressive therapy before transplantation in giant cell myocarditis and of the management of patients with positive cross-match in the context of a giant cell myocarditis.
Researchers ; Students
http://hdl.handle.net/2268/61547
10.1016/j.prp.2009.10.010
Copyright (c) 2009 Elsevier GmbH. All rights reserved.

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