ORBi: Blaker Jonny J. - Mechanical properties of highly porous PDLLA/Bioglass (R) composite foams as scaffolds for bone tissue engineering

Reference : Mechanical properties of highly porous PDLLA/Bioglass (R) composite foams as scaffolds f...


	Document type :	Scientific journals : Article
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry Engineering, computing & technology : Materials science & engineering
	To cite this reference:	http://hdl.handle.net/2268/6126

Title :	Mechanical properties of highly porous PDLLA/Bioglass (R) composite foams as scaffolds for bone tissue engineering
Language :	English
Author, co-author :	Blaker, Jonny J. [Imperial College, London, UK > Department of Materials and Centre for Tissue Engineering and Regenerative Medicine > > >]
	Maquet, Véronique [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Jérôme, Robert [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Boccaccini, Aldo R. [Imperial College, London > Department of Materials and Centre for Tissue Engineering and Regenerative Medicine > > >]
	Nazhat, S. N. [Eastman Dental Institute, University College London, UK > > Division of Biomaterials and Tissue Engineering > >]
Publication date :	Nov-2005
Journal title :	Acta Biomaterialia
Publisher :	Elsevier Sci Ltd
Volume :	1
Issue/season :	6
Pages :	643-652
Audience :	International
ISSN :	1742-7061
City :	Oxford
Keywords :	[en] biomaterial ; scaffold
Abstract :	[en] This study developed highly porous degradable composites as potential scaffolds for bone tissue engineering. These scaffolds consisted of poly-d,l-lactic acid filled with 2 and 15 vol.% of 45S5 Bioglass® particles and were produced via thermally induced solid–liquid phase separation and subsequent solvent sublimation. The scaffolds had a bimodal and anisotropic pore structure, with tubular macro-pores of 100 μm in diameter, and with interconnected micro-pores of 10–50 μm in diameter. Quasi-static and thermal dynamic mechanical analysis carried out in compression along with thermogravimetric analysis was used to investigate the effect of Bioglass® on the properties of the foams. Quasi-static compression testing demonstrated mechanical anisotropy concomitant with the direction of the macro-pores. An analytical modelling approach was applied, which demonstrated that the presence of Bioglass® did not significantly alter the porous architecture of these foams and reflected the mechanical anisotropy which was congruent with the scanning electron microscopy investigation. This study found that the Ishai–Cohen and Gibson–Ashby models can be combined to predict the compressive modulus of the composite foams. The modulus and density of these complex foams are related by a power-law function with an exponent between 2 and 3.
Research units :	Center for Education and Research on Macromolecules (CERM)
Funders :	The EPSRC (UK) ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/6126
DOI :	10.1016/j.actbio.2005.07.003
Other URL :	http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B7GHW-4H1006N-1-M&_cdi=20189&_user=532038&_orig=browse&_coverDate=11%2F30%2F2005&_sk=999989993&view=c&wchp=dGLbVtz-zSkzS&md5=443f29b4f5feded1980c5849856150eb&ie=/sdarticle.pdf
	http://www.elsevier.com/wps/find/journaldescription.cws_home/702994/description#description
Commentary :	The authors acknowledge Acta Biomaterialia (Elsevier) for allowing them to archive this paper.

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