Article (Scientific journals)
The Efficacy of Two Vaccination Schemes against Experimental Infection with a Virulent Amyxomatous or a Virulent Nodular Myxoma Virus Strain
Marlier, Didier; Mainil, Jacques; Boucraut-Baralon, C. et al.
2000In Journal of Comparative Pathology, 122 (2-3,), p. 115-22
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Abstract :
[en] Two types of myxomatosis vaccine are available commercially, namely, vaccine prepared from the Shope fibroma virus (SFV) and that prepared from an attenuated myxoma virus (MV) strain, e.gSG33. An experiment was designed to compare two vaccination schemes for their ability to protect rabbits against challenge with either a virulent amyxomatous MV strain or a virulent nodular MV strain. Apart from a difference in the cutaneous expression of the disease, the two challenge strains resembled each other in respect of mortality rate, naso-conjunctival shedding of virus, and tissue infection. Vaccination with SFV alone failed to prevent clinical signs, naso-conjunctival shedding or tissue infection. Vaccination with SFV followed by a booster inoculation with SG33 protected rabbits against the development of clinical signs and significantly reduced both viral shedding in naso-conjunctival exudates and viral infection of eyelids, lungs and testes; virus was, however, isolated from testes of some surviving animals.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Marlier, Didier  ;  Université de Liège - ULiège > Médecine des oiseaux, des lagomorphes et des rongeurs
Mainil, Jacques ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Bactériologie et pathologie des maladies bactériennes
Boucraut-Baralon, C.
Linden, Annick  ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Santé et pathologies de la faune sauvage
Vindevogel, Henri ;  Université de Liège - ULiège > Services généraux (Faculté de médecine vétérinaire) > Relations académiques et scientifiques (Méd. vétérinaire)
Language :
English
Title :
The Efficacy of Two Vaccination Schemes against Experimental Infection with a Virulent Amyxomatous or a Virulent Nodular Myxoma Virus Strain
Publication date :
2000
Journal title :
Journal of Comparative Pathology
ISSN :
0021-9975
Publisher :
W. B. Saunders Co., United Kingdom
Volume :
122
Issue :
2-3,
Pages :
115-22
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 February 2009

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