Reference : Penicillin and Beyond: Evolution, Protein Fold, Multimodular Polypeptides, and Multiprot...
Scientific journals : Article
Life sciences : Microbiology
http://hdl.handle.net/2268/61115
Penicillin and Beyond: Evolution, Protein Fold, Multimodular Polypeptides, and Multiprotein Complexes
English
Ghuysen, Jean-Marie [Université de Liège - ULg > > > > Centre d'ingénierie des protéines > >]
Charlier, Paulette mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Coyette, Jacques [> >]
Duez, Colette mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Fonze, Eveline [> > > >]
Fraipont, Claudine mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Joris, Bernard mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Nguyen-Distèche, Martine mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Goffin, Colette mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
1996
Microbial Drug Resistance : Mechanism, Epidemiology, & Disease
Mary Ann Liebert, Inc.
2
2, Summer
163-175
Yes (verified by ORBi)
International
1076-6294
1931-8448
Larchmont
NY
[en] Penicillin ; Antibiotic
[en] As the protein sequence and structure databases expand, the relationships between proteins, the notion of protein superfamily, and the driving forces of evolution are better understood. Key steps of the synthesis of the bacterial cell wall peptidoglycan are revisited in light of these advances. The reactions through which the D-alanyl-D-alanine depeptide is formed, utilized, and hydrolyzed and the sites of action of the glycopeptide and beta-lactam antibiotics illustrate the concept according to which new enzyme functions evolve as a result of tinkering of existing proteins. This occurs by the acquisition of local structural changes, the fusion into multimodular polypeptides, and the association into multiprotein complexes.
Centre d'ingénierie des protéines - CIP
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/61115
This is a copy of an article published in the Microbial Drug Resistance : Mechanism, Epidemiology, & Disease © 1996 [copyright Mary Ann Liebert, Inc.]; Microbial Drug Resistance : Mechanism, Epidemiology, & Disease is available online at: http://www.liebertonline.com.

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