Article (Scientific journals)
Study of the Virulence of Five Strains of Amyxomatous Myxoma Virus in Crossbred New Zealand White/Californian Conventional Rabbits, with Evidence of Long-Term Testicular Infection in Recovered Animals
Marlier, Didier; Mainil, Jacques; Sulon, Joseph et al.
2000In Journal of Comparative Pathology, 122 (2-3, Feb-Apr), p. 101-13
Peer Reviewed verified by ORBi
 

Files


Full Text
crossbred.pdf
Publisher postprint (142.63 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] The virulence of five amyxomatous myxoma virus (MV) strains, the clinical and pathogenetic effects of which had been studied previously in specific pathogen-free (SPF) rabbits, was determined by inoculation of five groups of 10 crossbred New Zealand White/Californian conventional rabbits. A much more acute myxomatosis syndrome was produced in conventional rabbits than that reproduced previously in SPF animals. However, the main clinical signs were of the respiratory type. The MV strains MYX 254/95 and 801 appeared very virulent, killing all the inoculated animals. The strains MYX 217/95, MYX 555/94 and Saint Benoist were somewhat attenuated, killing only seven, six and six rabbits, respectively. Extensive lung lesions due to supervening bacterial infections were observed in 36 of the 39 rabbits that died. Lethality was found to be a better estimate of virulence than mean survival time. By 98 days after viral inoculation, all the surviving animals had completely recovered. At that time, they were immunosuppressed by treatment with adrenocorticotrophic hormone (ACTH) for 10 days to determine whether they still harboured the virus. After the ACTH treatment, eight of the 11 surviving rabbits showed clinical signs that resembled amyxomatous myxomatosis. All the virological examinations performed on naso-conjunctival exudate, on mononuclear cells, on eyelids and on ovaries remained negative but infectious virus was isolated from the testes of three of six surviving male rabbits.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Marlier, Didier  ;  Université de Liège - ULiège > Médecine des oiseaux, des lagomorphes et des rongeurs
Mainil, Jacques ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Bactériologie et pathologie des maladies bactériennes
Sulon, Joseph ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Beckers, Jean-François  ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Linden, Annick  ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Santé et pathologies de la faune sauvage
Vindevogel, Henri ;  Université de Liège - ULiège > Services généraux (Faculté de médecine vétérinaire) > Relations académiques et scientifiques (Méd. vétérinaire)
Language :
English
Title :
Study of the Virulence of Five Strains of Amyxomatous Myxoma Virus in Crossbred New Zealand White/Californian Conventional Rabbits, with Evidence of Long-Term Testicular Infection in Recovered Animals
Publication date :
2000
Journal title :
Journal of Comparative Pathology
ISSN :
0021-9975
Publisher :
Academic Press, Liverpool, United Kingdom
Volume :
122
Issue :
2-3, Feb-Apr
Pages :
101-13
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 February 2009

Statistics


Number of views
96 (13 by ULiège)
Number of downloads
1 (1 by ULiège)

Scopus citations®
 
25
Scopus citations®
without self-citations
23
OpenCitations
 
21

Bibliography


Similar publications



Contact ORBi