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| Reference : Both Pituitary and Placental Growth Hormone Transcripts Are Expressed in Human Periphera... |
| Scientific journals : Article | |||
| Human health sciences : Immunology & infectious disease | |||
| http://hdl.handle.net/2268/610 | |||
| Both Pituitary and Placental Growth Hormone Transcripts Are Expressed in Human Peripheral Blood Mononuclear Cells (Pbmc) | |
| English | |
Melen-Lamalle, Laurence  [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >] | |
| Hennen, Georges [Centre Hospitalier Universitaire de Liège - CHU > > Endocrinologie clinique >] | |
| Dullaart, R. P. [> > > >] | |
| Heinen, Ernst [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >] | |
| Igout, Ahmed [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >] | |
| Nov-1997 | |
| Clinical & Experimental Immunology | |
| 110 | |
| 2 | |
| 336-40 | |
| International | |
| 0009-9104 | |
| [en] hGH-V ; pregnancy ; peripheral blood monnuclear cells | |
| [en] The hGH-V gene codes for a variant of human pituitary growth hormone (hGH-N) named placental growth hormone (hPGH). hPGH shares 93% amino acid identity with hGH-N. Until now the hGH-V gene was considered to be exclusively expressed in human placenta, where it replaces maternal circulating hGH-N at the end of pregnancy. In this study we investigated by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis hGH-N, and hGH-V, gene expression in PBMC in men, women and pregnant women. We have demonstrated that hGH-N and hGH-V transcripts are simultaneously produced by PBMC in both men and women as well as pregnant women. The PBMC of a PIT-1-negative woman expressed only the hGH-V transcript, but not the hGH-N one as expected. In conclusion, hGH-V mRNA is expressed by cells other than the syncytiotrophoblast, is not regulated by PIT-1, and may be involved in immune regulation, as is pituitary GH. | |
| Researchers ; Professionals ; Students | |
| http://hdl.handle.net/2268/610 |
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