Reference : Effect of different contraceptive methods on the oxidative stress status in women aged 4...
Scientific journals : Article
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
http://hdl.handle.net/2268/6087
Effect of different contraceptive methods on the oxidative stress status in women aged 40-48 years from the ELAN study in the province of Liege, Belgium
English
Pincemail, Joël [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
Vanbelle, Sophie mailto [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique >]
Gaspard, Ulysse [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)]
Collette, Georges [Université de Liège - ULg > Département des sciences cliniques > Médecine générale >]
Haleng, Jeanine [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
Cheramy-Bien, J. P. [> > > >]
Charlier, Corinne mailto [Université de Liège - ULg > Département de pharmacie > Chimie toxicologique]
Chapelle, Jean-Paul [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Giet, Didier [Université de Liège - ULg > > IFRES >]
Albert, Adelin [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique >]
Limet, Raymond [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique]
Defraigne, Jean-Olivier [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie générale]
Aug-2007
Human Reproduction
Oxford Univ Press
22
8
2335-2343
Yes (verified by ORBi)
International
0268-1161
Oxford
[en] oxidative stress ; antioxidants ; oral contraception ; ELAN study
[en] Oxidative stress is associated with the development of several disorders including cardiovascular disease and cancer. Among conditions known to influence oxidative stress, the use of oral contraception (OC) in women has been a matter of ongoing discussion. METHODS: A total of 897 eligible and healthy volunteers were recruited from among the patients of 50 general practitioners participating in the ELAN study (Etude Liegeoise sur les ANtioxydants). A subsample consisting of 209 women aged 40-48 years was studied for a comprehensive oxidative stress status (OSS), including the analysis of antioxidants, trace elements and three markers of oxidative damage to lipids. Among 209 subsample, 49 (23%) were OC users (OCU), 119 (57%) non-contraception users (NCU) and 41 (20%) were intrauterine (hormonal and copper) devices users (IUD). RESULTS: After adjustment for smoking, systolic and diastolic blood pressure and BMI (or waist circumference), a marked and significant increase in lipid peroxides was observed among OCU women when compared with NCU and IUD users. A cut-off value of 660 mu M in lipid peroxides allowed the discrimination of OCU from the two other groups. In contrast, no difference was observed in the plasma concentration of both oxidized low-density lipoprotein (LDL) and their related antibodies. The increased level in lipid peroxides was strongly related to higher concentrations of copper (r < 0.84; P < 0.0001, cut-off value 1.2 mg/1). When compared with NCU and IUD users, plasma antioxidant defences were significantly altered in OCU women as shown by lower levels of beta-carotene (decrease of 39%; P < 0.01) andytocopherol (decrease by 22%; P < 0.01). In contrast, higher concentrations of selenium (increased by 11.8%; P < 0.01) were observed in OCU women. Blood concentrations of vitamin C, alpha-tocopherol and zinc were unaffected by OC use. CONCLUSIONS: The intake of OC significantly increases the lipid peroxidation in women aged 40-48 years. This may represent a potential cardiovascular risk factor for these women.
http://hdl.handle.net/2268/6087
10.1093/humrep/dem146
http://humrep.oxfordjournals.org/cgi/reprint/22/8/2335
http://humrep.oxfordjournals.org/

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