Reference : Development of response models for optimising HPLC methods
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/6036
Development of response models for optimising HPLC methods
English
Dewé, Walthère [Université de Liège - ULg > > Analyse des médicaments >]
Marini Djang'Eing'A, Roland mailto [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
Chiap, Patrice mailto [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
Hubert, Philippe mailto [Université de Liège - ULg > > Chimie analytique >]
Crommen, Jacques mailto [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
Boulanger, Bruno [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
28-Dec-2004
Chemometrics and Intelligent Laboratory Systems
Elsevier Science Bv
74
2
263-268
Yes (verified by ORBi)
International
0169-7439
Amsterdam
[en] liquid chromatography ; retention time ; optimization ; modeling ; multi-criteria decision
[en] For optimizing a liquid chromatographic method, direct modeling some responses like minimum resolution is sometimes difficult to perform. By modeling the retention time at apex and the times associated to 13.4% of the peak height, it is possible to obtain estimations of these responses using an adequate cascade of equations, these equations being the definitions of these responses. As a multi-criteria decision has to be taken in most of these optimizations, a Derringer's function can be defined for each response of interest and a overall desirability, on which the final is taken, can be derived. In addition, the chromatogram in any experimental point can be predicted. (C) 2004 Elsevier B.V. All rights reserved.
http://hdl.handle.net/2268/6036

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