Reference : Mammosomatotropes in Human Pituitary Adenomas as Revealed by Electron Microscopic Dou...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Mammosomatotropes in Human Pituitary Adenomas as Revealed by Electron Microscopic Double Gold Immunostaining Method
Beckers, Albert mailto [Université de Liège - ULg > Département des sciences cliniques > Endocrinologie]
Courtoy, R. [ > > ]
Stevenaert, Achille [Université de Liège - ULg > > Neurochirurgie >]
Boniver, Jacques [Université de Liège - ULg > > Anatomie pathologique >]
Lange, J. M. [ > > ]
Frankenne, Francis [ > > ]
Reznik, Michel [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Hennen, Georges [Université de Liège - ULg > > Endocrinologie clinique >]
Acta Endocrinologica
Yes (verified by ORBi)
[en] Hormone production was studied in situ by immunocytochemical methods in 20 pituitary adenomas. Special attention was given to 13 adenomas removed from acromegalic patients. Out of them, 6 had mild to moderate hyperprolactinemia. Immunohistochemistry revealed PRL-containing cells without any close relationship with high PRL serum level in 6 patients. Double immunogold staining revealed mammosomatotrope cells characterized by simultaneous presence of GH and PRL in the same granules in 2 patients. Since mammosomatotropes have never been demonstrated in the normal pituitary, our results probably signify gene dysregulation in pituitary cells of those acromegalic patients.

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