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| Reference : Mammosomatotropes in Human Pituitary Adenomas as Revealed by Electron Microscopic Double... |
| Scientific journals : Article | |||
| Human health sciences : Endocrinology, metabolism & nutrition | |||
| http://hdl.handle.net/2268/60259 | |||
| Mammosomatotropes in Human Pituitary Adenomas as Revealed by Electron Microscopic Double Gold Immunostaining Method | |
| English | |
Beckers, Albert  [Université de Liège - ULg > Département des sciences cliniques > Endocrinologie] | |
| Courtoy, R. [ > > ] | |
| Stevenaert, Achille [Université de Liège - ULg > > Neurochirurgie >] | |
| Boniver, Jacques [Université de Liège - ULg > > Anatomie pathologique >] | |
| Lange, J. M. [ > > ] | |
| Frankenne, Francis [ > > ] | |
| Reznik, Michel [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >] | |
| Hennen, Georges [Université de Liège - ULg > > Endocrinologie clinique >] | |
| Aug-1988 | |
| Acta Endocrinologica | |
| Periodica | |
| 118 | |
| 4 | |
| 503-12 | |
| 0001-5598 | |
| Copenhagen | |
| Denmark | |
| [en] Hormone production was studied in situ by immunocytochemical methods in 20 pituitary adenomas. Special attention was given to 13 adenomas removed from acromegalic patients. Out of them, 6 had mild to moderate hyperprolactinemia. Immunohistochemistry revealed PRL-containing cells without any close relationship with high PRL serum level in 6 patients. Double immunogold staining revealed mammosomatotrope cells characterized by simultaneous presence of GH and PRL in the same granules in 2 patients. Since mammosomatotropes have never been demonstrated in the normal pituitary, our results probably signify gene dysregulation in pituitary cells of those acromegalic patients. | |
| http://hdl.handle.net/2268/60259 |
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