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Article (Scientific journals)
Cyclical Cushing's disease : a case report.
Velkeniers, B.; Beckers, Albert; Stevenaert, Achille et al.
1991In Pathology - Research and Practice, 187 (5), p. 603-607
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Keywords :
Cushing's syndrome; ACTH hypersecretion; biochemical remission; clinical remissino; Cushing's disease; circadian hyperpulsatile ACTH; cortisol secretion
Abstract :
[en] A 41-year-old man with clinical Cushing's syndrome and intermittent central ACTH hypersecretion for a period of 9 1/2 years follow-up is described. Episodes of biochemical and clinical remission alternated with periods of florid Cushing's disease, characterized by circadian hyperpulsatile ACTH and cortisol secretion. Responses to metyrapone and inhibition of ACTH and cortisol hypersecretion after high dose dexamethasone during active phases of the disease favored a central origin of ACTH hypersecretion, confirmed by simultaneous bilateral venous sampling of the sinus petrosus inferior. Prolonged clinical remission followed near total anterior hypophysectomy. However, on anatomopathological examination of the pituitary neither corticotroph cell hyperplasia nor a microadenoma could be documented. The possibility of a functional ACTH hypersecretion is discussed.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Velkeniers, B.
Beckers, Albert ;  Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie
Stevenaert, Achille ;  Université de Liège - ULiège > Neurochirurgie
Smits, J.
Finne, E.
Vanhaelst, L.
Language :
English
Title :
Cyclical Cushing's disease : a case report.
Publication date :
1991
Journal title :
Pathology - Research and Practice
ISSN :
0344-0338
eISSN :
1618-0631
Publisher :
Gustav Fischer Verlag, Stuttgart, Germany
Volume :
187
Issue :
5
Pages :
603-607
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 May 2010

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