Reference : Improvement of the decision efficiency of the accuracy profile by means of a desirabilit...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/6022
Improvement of the decision efficiency of the accuracy profile by means of a desirability function for analytical methods validation - Application to a diacetyl-monoxime colorimetric assay used for the determination of urea in transdermal iontophoretic extracts
English
Rozet, Eric mailto [Université de Liège - ULg > > Chimie analytique >]
Wascotte, Valentine [Université Catholique de Louvain - UCL > School of Pharmacy > Pharmaceutical Technology Department >]
Lecouturier, Nathalie [Université Catholique de Louvain - UCL > School of Pharmacy > Pharmaceutical Technology Department >]
Préat, Véronique [Université Catholique de Louvain - UCL > School of Pharmacy > Pharmaceutical Technology Department >]
Dewé, Walthère [Université de Liège - ULg > > Analyse des médicaments >]
Boulanger, Bruno [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
Hubert, Philippe mailto [Université de Liège - ULg > > Chimie analytique >]
May-2007
Analytica Chimica Acta
Elsevier Science Bv
591
2
239-247
Yes (verified by ORBi)
International
0003-2670
1873-4324
Amsterdam
[en] colorimetric method ; iontophoretic extracts ; validation ; accuracy profile ; tolerance interval ; desirability index
[en] Validation of analytical methods is a widely used and regulated step for each analytical method. However, the classical approaches to demonstrate the ability to quantify of a method do not necessarily fulfill this objective. For this reason an innovative methodology was recently introduced by using the tolerance interval and accuracy profile, which guarantee that a pre-defined proportion of future measurements obtained with the method will be included within the acceptance limits. Accuracy profile is an effective decision tool to assess the validity of analytical methods. The methodology to build such a profile is detailed here. However, as for any visual tool it has a part of subjectivity. It was then necessary to make the decision process objective in order to quantify the degree of adequacy of an accuracy profile and to allow a thorough comparison between such profiles. To achieve this, we developed a global desirability index based on the three most important validation criteria: the trueness, the precision and the range. The global index allows the classification of the different accuracy profiles obtained according to their respective response functions. A diacetyl-monoxime colorimetric assay for the determination of urea in transdermal iontophoretic extracts was used to illustrate these improvements.
Researchers ; Professionals
http://hdl.handle.net/2268/6022
10.1016/j.aca.2007.04.002

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
ACA228365.pdfNo commentaryAuthor postprint951.01 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.