No full text
Article (Scientific journals)
Presurgical octreotide treatment in acromegaly.
Stevenaert, Achille; Harris, A. G.; Kovacs, K. et al.
1992In Metabolism: Clinical and Experimental, 41 (9 Suppl. 2), p. 51-8
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Acromegaly/drug therapy/metabolism/pathology/surgery; Adenoma/metabolism/pathology/surgery; Adult; Female; Growth Hormone/blood; Humans; Insulin-Like Growth Factor I/metabolism; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Octreotide/administration & dosage/therapeutic use; Pituitary Neoplasms/metabolism/pathology/surgery; Tomography, X-Ray Computed; Treatment Outcome
Abstract :
[en] The aim of this study was to determine the role of octreotide administration in acromegalic patients as a preparation for selective adenomectomy using transsphenoidal route. Octreotide was administered for 3 to 6 weeks before surgery in 12 patients and for 4 to 39 months in 25 patients. The clinical response was judged as excellent or good in 10 of 12 patients from group I and in 23 of 25 patients from group II. Marked reduction (ie, greater than 50% of initial values) in serum growth hormone (GH) levels was seen in all patients, with levels to less than 5 micrograms/L in 68% of patients and less than 2 micrograms/L in 27%. Insulin-like growth factor 1 (IGF-1) levels decreased to within normal limits in half the cases. During long-term treatment, an escape phenomenon could be seen. Varying degrees of tumor shrinkage were seen in more than 50% of cases. During surgery, with regard to the relative ease or difficulty in removing the tumor, the consistency of the tumor and the separation of normal from pathological tissue, no significant difference was observed between patients given octreotide and those from control series. Morphological changes in adenomatous tissue were rather small. The surgical outcome was similar in the pretreated series as in the control series, except in enclosed adenomas, which showed a tendency to a higher success rate. Since octreotide improves both the clinical condition and hormonal parameters and induces varying degrees of tumor shrinkage, it is potentially useful as an adjunct to surgery. Morphological data suggest that octreotide exercises a functional inhibitory effect on GH release.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Stevenaert, Achille ;  Centre Hospitalier Universitaire de Liège - CHU > Neurochirurgie
Harris, A. G.
Kovacs, K.
Beckers, Albert ;  Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie
Language :
English
Title :
Presurgical octreotide treatment in acromegaly.
Publication date :
September 1992
Journal title :
Metabolism: Clinical and Experimental
ISSN :
0026-0495
eISSN :
1532-8600
Publisher :
W.B. Saunders, Philadelphia, United States - Pennsylvania
Volume :
41
Issue :
9 Suppl. 2
Pages :
51-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 June 2010

Statistics


Number of views
32 (3 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
56
Scopus citations®
without self-citations
50
OpenCitations
 
41

Bibliography


Similar publications



Contact ORBi