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| Reference : Controlled synthesis of an ABC miktoarm star-shaped copolymer by sequential ring-opening... |
| Scientific journals : Article | |||
| Physical, chemical, mathematical & earth Sciences : Chemistry Engineering, computing & technology : Materials science & engineering | |||
| http://hdl.handle.net/2268/6010 | |||
| Controlled synthesis of an ABC miktoarm star-shaped copolymer by sequential ring-opening polymerization of ethylene oxide, benzyl beta-malolactonate, and epsilon-caprolactone | |
| English | |
| Rieger, Jutta [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >] | |
| Coulembier, Olivier [University of Mons-Hainaut (UMH) > > Laboratory of Polymeric and Composite Materials > >] | |
| Dubois, Philippe [University of Mons-Hainaut (UMH) > > Laboratory of Polymeric and Composite Materials > >] | |
| Bernaerts, Katrien V. [University of Ghent > Department of Organic Chemistry > Polymer Chemistry Research Group > >] | |
| Du Prez, Filip E. [University of Ghent > Department of Organic Chemistry > Polymer Chemistry Research Group > >] | |
Jérôme, Robert  [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >] | |
| Jérôme, Christine [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >] | |
| 27-Dec-2005 | |
| Macromolecules | |
| Amer Chemical Soc | |
| 38 | |
| 26 | |
| 10650-10657 | |
| Yes (verified by ORBi) | |
| International | |
| 0024-9297 | |
| Washington | |
| [en] ring-opening polymerization (ROP) ; star-shaped polymer | |
| [en] This paper reports on the synthesis of an amphiphilic miktoarm ABC star-shaped copolymer, s[(PEO)(PMLABz)(PCL)], consisting of biocompatible/bioresorbable arms. Indeed, PEO is a hydrophilic biocompatible poly(ethylene oxide) arm, PMLABz is a poly(benzyl beta-malolactonate) arm precursor of a pH-sensitive bioresorbable poly(beta-malic acid) block, and PCL is a hydrophobic bioresorbable poly(epsilon-caprolactone) arm. Each constitutive arm was prepared by ring-opening polymerization. A double-headed PEO macroinitiator [PEO-(OH)-COO-K+] was first prepared by selective hydrolysis of the alpha-lactone (2-oxepanone) end group of PEO chains end-capped by a omega-methoxy group. The anionic polymerization of benzyl beta-malolactonate (MLABz) was selectively initiated by the alpha-potassium carboxylate end group of PEO in the presence of 18-crown-6 ether. The polymerization of epsilon-caprolactone (epsilon-CL) was initiated by the hydroxyl group left at the junction of the two blocks of the as-prepared PEO-b-PMLABz diblock copolymer, in the presence of tin(II) bis(2-ethylhexanoate) (Sn(Oct)(2)). The macroinitiator, the intermediate diblock, and the final miktoarm. star-shaped copolymer were analyzed by H-1 NMR spectroscopy and size exclusion chromatography. | |
| Center for Education and Research on Macromolecules (CERM) | |
| Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds Wetenschappelijk Onderzoek - FWO ; Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; The Région Wallonne and Fonds Social Européen in the frame of Objectif 1-Hainaut: Materia Nova program | |
| Researchers | |
| http://hdl.handle.net/2268/6010 | |
| 10.1021/ma051581l | |
| http://pubs.acs.org/doi/pdf/10.1021/ma051581l |
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