ORBi: Kung Annie Wai-Chee - Impact of bone marker feedback on adherence to once monthly ibandronate for osteoporosis among Asian postmenopausal women

Reference : Impact of bone marker feedback on adherence to once monthly ibandronate for osteoporosis...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Rheumatology
	To cite this reference:	http://hdl.handle.net/2268/60002

Title :	Impact of bone marker feedback on adherence to once monthly ibandronate for osteoporosis among Asian postmenopausal women
Language :	English
Author, co-author :	Kung, Annie Wai-Chee [ > > ]
	Rachman, A Ichramsjah [ > > ]
	Adam, MF John [ > > ]
	Roeshadi, Djoko [ > > ]
	Torralba, Tito [ > > ]
	Navarra, Sandra [ > > ]
	Gamilla, Zayda [ > > ]
	Cañete, Arthur [ > > ]
	de la Rosa, Miles [ > > ]
	Tsai, KehSung [ > > ]
	Lin, Hsiao-Yi [ > > ]
	Soong, Yung Kuei [ > > ]
	Lan, Joung-Liang [ > > ]
	Hsu, Horng-Chaung [ > > ]
	Tu, Shih-Te [ > > ]
	Lin, Ruey-Mo [ > > ]
	Yuktanandana, Pongsak [ > > ]
	Songpatanasilp, Thawee [ > > ]
	Ngarmukos, Srihatach [ > > ]
	Soontrapa, Sugree [ > > ]
	Soontrapa, Suppasin [ > > ]
	Rojanasthien, Sattaya [ > > ]
	Luevitoonvechkij, Sirichai [ > > ]
	Leerapan, Taninnit [ > > ]
	Albert, Adelin [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique - Département de mathématique >]
	Vanbelle, Sophie [Université de Liège - ULg > Département de mathématique > Département de mathématique >]
Publication date :	2009
Journal title :	International Journal of Rheumatic Diseases
Volume :	12
Pages :	216-224
Audience :	International
Keywords :	[en] adherence ; bone marker ; compliance ; feedback ; ibandronate ; osteoporosis
Abstract :	[en] Aim: This study assesses the impact of serum carboxy-terminal collagen crosslinks (CTX) bone marker feedback (BMF) on adherence to ibandronate treatment in Asian postmenopausal women with osteoporosis. Methods: This was a 12-month (6-monthly phased), randomized, prospective, open-label, multi-center study conducted in 596 (of 628 enrolled) postmenopausal women with osteoporosis (£ 85 years old) who were naı¨ve, lapsed, or current bisphosphonate users. Patients were randomized into two arms: serum CTX BMF at 3 months versus no-BMF. Once-monthly 150 mg ibandronate tablet was administered for 12 months and adherence to therapy was assessed at 6 and 12 months. In addition, patient satisfaction and safety of ibandronate treatment were also assessed. Results: Serum CTX BMF at 3 months showed no impact on adherence. The proportions of adherent patients were comparable in the BMF versus no-BMF arms (92.6% vs. 96.0%, P = 0.16); overall, serum CTX levels were similar for adherent and non-adherent patients. However, BMF patients felt more informed about their osteoporosis (P < 0.001) and more satisfied (P < 0.01) than no-BMF patients. Conclusions: The Asian postmenopausal osteoporosis patients in this study had a high adherence rate to once-monthly ibandronate therapy. Use of serum CTX BMF had no further impact on increasing adherence, but increased treatment satisfaction.
Name of the research project :	the BonAdAsia study group
Permalink :	http://hdl.handle.net/2268/60002
DOI :	10.1111/j.1756-185X.2009.01413.x

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	bonadasia.pdf		Publisher postprint	180.33 kB	Request copy

All documents in ORBi are protected by a user license.

Dspace v1.5