Andropause and psychopathology: minor symptoms rather than pathological ones.

Aged; Aging; Anxiety/epidemiology; Depression/epidemiology; Follicle Stimulating Hormone/blood; Humans; Hypogonadism/etiology/psychology; Luteinizing Hormone/blood; Male; Middle Aged; Quality of Life; Sex Hormone-Binding Globulin/analysis; Sleep Initiation and Maintenance Disorders/epidemiology; Testosterone/blood

Abstract :

[en] This study examined the psychological symptomatology of men diagnosed with andropause and the association between calculated free testosterone (T) and depressed mood, anxiety and quality of life. Subjects were 153 men, aged 50-70 years, who participated in a screening of andropause. Total testosterone, FSH, LH and SHBG levels were measured. Depressed mood was assessed with the Carroll Rating Scale, anxiety with the "anxiety-insomnia" dimension of the General Health Questionnaire, and quality of life with the World Health Organisation Quality of Life questionnaire. The results showed that levels of free T decreased with age, whereas FSH and LH increased. Carroll Rating Scale scores were higher among hypogonadal subjects, but the mean score was low and not pathological. A negative correlation was observed between severity of depression as assessed by the Carroll Rating Scale and free T levels. However, subjects with a significant score on this scale did not exhibit different free T levels compared to subjects with a non-significant depressive score. Anxiety and quality of life did not differ between hypogonadal and eugonadal subjects. The present study therefore suggests that andropause is not characterised by specific psychological symptoms, but may be associated with "depressive symptoms" that are not considered as pathological.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Delhez, Marie

Hansenne, Michel ; Université de Liège - ULiège > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles

Legros, Jean-Jacques ; Centre Hospitalier Universitaire de Liège - CHU > Endocrinologie clinique

Language :

English

Title :

Andropause and psychopathology: minor symptoms rather than pathological ones.

Publication date :

2003

Journal title :

Psychoneuroendocrinology

ISSN :

0306-4530

eISSN :

1873-3360

Publisher :

Pergamon Press - An Imprint of Elsevier Science, Oxford, United Kingdom

Volume :

Issue :

Pages :

863-74

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 10 February 2009

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Bibliography

Amsterdam J.D., Winokur A., Caroff S., Snyder P. Gonadotropin release after administration of GnRH in depressed patients and healthy volunteers. J. Affect. Disord. 3:1981;367-380.
Anderson R.A., Bancroft J., Wu F.C. The effects of exogenous testosterone on sexuality and mood of normal men. J. Clin. Endocr. Metab. 75:1992;1503-1507.
Barrett-Connor E., Von Mühlen D.G., Kritz-Silverstein D. Bioavailable testosterone and depressed mood in older men: The Rancho Bernardo study. J. Clin. Endocr. Metab. 84:1999;573-577.
Bhasin S., Bagatell C.J., Bremner W.J., Plymate S.R., Tenover J.L., Korenman S.G., Nieschlag E. Therapeutic perspective: Issues in testosterone replacement in older men. J. Clin. Endocr. Metab. 83:1998;3435-3448.
Bouillon, G., Charlier, C., Delhez, M., Vroonen, L., Luyckx, F., De Graeve, J., Plomteux, G., Legros, J.J., 2001. L'insuffisance gonadotrope relative (IGR) de l'homme âgé de 50 à 70 ans n'est pas secondaire à une imprégnation excessive en pesticides organochlorés. Annales d'Endocrinol. 62 (4), cahier 1.
Burns-Cox N., Gingell C. The andropause: fact or fiction? Postgrad. Med. J. 73:1997;553-556.
Burris A.S., Banks S.M., Carter C.S., Davidson J.M., Sherins R.J. A long-term, prospective study of the physiologic and behavioral effects of hormone replacement in untreated hypogonadal men. J. Androl. 13:1992;297-304.
Carroll B.J., Feinberg M., Smouse P.E., Rawson S.G., Greden J.F. The Carroll rating scale for depression: I. Development, reliability and validation. Br. J. Psychiat. 138:1981;194-200.
Davies R.H., Harris B., Thomas D.R., Cook N., Read G., Riad-Fahmy D. Salivary testosterone levels and major depressive illness in men. Br. J. Psychiat. 161:1992;629-632.
Deslypere J.P., Kaufman J.M., Vermeulen T., Vogelaers D., Vandalen J.L., Vermeulen A. Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men. J. Clin. Endocrinol. Metab. 64:1987;68-73.
Franchimont P., Millet D., Vendrely E., Letawe J., Legros J.J., Netter A. Relationship between spermatogenesis and serum gonadotrophin levels in azoospermia and oligospermia. J. Clin. Endocr. Metab. 34:1972;1003-1008.
Goldberg D.P., Hillier J.F. A scaled version of the General Health Questionnaire. Psychol. Med. 9:1979;139-145.
Gray A., Feldman H.A., McKinlay J.B., Longcope A. Age, disease and changing sex hormone levels in the middle-aged men: result of the Massachusetts male aging study. J. Clin. Endocr. Metab. 73:1991;1016-1023.
Harman S.M., Tsitouras P.D. Reproductive hormone in aging male. I. Measurement of sex steroids, basal luteinizing hormone and Leydig cell response to human chorionic gonadotropin. J. Clin. Endocr. Metab. 51:1980;35-40.
Harman S.M., Metter E.J., Tobin J.D., Pearson J., Blackman M.R. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J. Clin. Endocr. Metab. 86:2001;724-731.
Heindrick V., Giltin M., Altshuler L., Korenman S. Antidepressant medications, mood and male fertility. Psychoneuroendocrinology. 25:2000;37-51.
Legros J.J. The aging male clinic from a European perspective. The Aging Male. 4:2001;209.
Legros J.J., Franchimont P., Burger H., Demoulin A. Influence d'une dose faible d'œstradiol sur la libération pulsatile des gonadotrophines et sur la libération hypophysaire sous l'influence du LRH chez l'homme normal. C. R. Soc. Biol. 168:(1432-144):1974;2.
Legros J.J., Bruwier M. La fonction endocrinienne au cours du vieillissement. Bourlière M. Précis de Gérontologie. 1979;62-80 Flammarion, Paris.
Legros J.J., Delmotte P. Le système de contrôle hypothalamo-hypophysaire est-il modifié au cours du vieillissement chez l'homme? Rev. Med. Liège. 52:1997;209-214.
Legros J.J., Delhez M. Utilisation d'une version française du test A.D.A.M. La déficience androgénique chez l'homme de plus de 50 ans. Med. Hyg. 60:2002;1490-1495.
Levitt A.J., Joffe R.T. Total and free testosterone in depressed men. Acta Psychiatr. Scand. 77:1988;346-348.
Mahmoud A.M., Goemaere S., De Bacquer D., Comhaire F.H., Kaufman J.M. Serum inhibin B levels in community-dwelling elderly men. Clin. Endocrinol. 53:(2):2000;141-147.
Mason J.W., Giller E.L., Kosten T.R. Serum testosterone differences between patients with schizophrenia and those with affective disorder. Biol. Psychiat. 23:1988;357-366.
Meacham R.B., Murray M.J. Reproductive function in the ageing male. Urol. Clin. North Am. 21:1994;549-556.
Metz M.E., Miner M.H. Male "menopause" aging and sexual function: a review. Sex. Disabil. 13:1995;287-307.
Morales A., Johnston B., Heaton J.W.P., Clark A. Oral androgens in the treatment of hypogonadal impotent men. J. Urol. 152:1994;1115-1118.
Morley J.E., Kaiser F.E., Perry H.M. III, Patrick P., Morley P.M.K., Stauber P.M., Vellas B., Baumgartner R.N., Garry P.J. Longitudinal changes in testosterone, luteinizing hormone, and folliculo-stimulating hormone in healthy older men. Metabolism. 46:1997;410-413.
Morley J.E., Kaiser F.E., Sih R., Hajjar R., Perry H.M. II. Testosterone and frailty. Clin. Geriatr. Med. 13:1997;685-695.
Murphy S., Khaw K., Cassidy A., Compston J.F. Sex hormones and bone mineral density in elderly men. Bone Miner. 20:1993;133-140.
O'Carroll R., Shapiro C., Bancroft J. Androgens, behaviour, and nocturnal erection in hypogonadal men: the effects of varying the replacement dose. Clin. Endocrinol. 23:1985;527-538.
Olewus D., Mattsson A., Schalling D., Low H. Testosterone, aggression physical, and personality dimensions in normal adolescent males. Psychosom. Med. 42:1980;253-269.
Perry P.J., Lund B.C., Arndt S., Holman T., Bever-Stille K.A., Paulsen J., Demers L. Bioavailable testosterone as a correlate of cognition, psychological status, quality of life, and sexual function in aging males: Implications for testosterone replacement therapy. Ann. Clin. Psychiat. 13:2001;75-80.
Rabkin J.G., Rabkin R., Wagner G. Testosterone replacement therapy in HIV illness. Gen. Hosp. Psychiat. 17:1995;37-42.
Rabkin J.G., Wagner G., Rabkin R. Testosterone therapy for human immunodeficiency virus-positive men with and without hypogonadism. J. Clin. Psychopharmacol. 19:1999;19-27.
Rinieris P.M., Malliaras D.E., Batrinos M.L., Stefanis C.N. Testosterone treatment of depression in two patients with Klinefelter's syndrome. Am. J. Psychiat. 136:1979;986-988.
Rubin R.T., Poland R.E., Lesser I.M. Neuroendocrine aspects of primary endogenous depression VIII: pituitary-gonadal axis activity in male patients and matched control subjects. Psychoneuroendocrinology. 14:1989;217-229.
Rupprecht R., Rupprecht C., Rupprecht M., Noder M., Schwarz W. Different reactivity of the hypothalamo-pituitary-gonadal-axis in depression and normal controls. Pharmacopsychiatry. 21:1988;438-439.
Sachar E.J., Halpern F., Rosenfeld R.S., Gallagher T.F., Hellman L. Plasma and urinary testosterone levels in depressed men. Arch. Gen. Psychiat. 28:1973;15-18.
Schiavi R.C., Rehman J. Sexuality and aging. Urol. Clin. North Am. 22:1995;711-726.
Schow D.A., Redmon B., Pryor J.L. Male menopause: how to definite it, how to treat it. Psychol. Med. 101:1997;62-79.
Schweiger U., Deuschle M., Weber B., Körner A., Lammers C-L., Schmider J., Gotthardt U., Heuser I. Testosterone, gonadotropin, and cortisol secretion in male patients with major depression. Psychosom. Med. 61:1999;292-296.
Seidman S.N., Rabkin J.G. Testosterone replacement therapy for hypogonadal men with SSRI-refractory depression. J. Affect. Disord. 48:1998;157-161.
Seidman S.N., Araujo A.B., Roose S.P., Devanand D.P., Xie S., Cooper T.B., McKinlay J.B. Low testosterone levels in elderly men with dysthymic disorder. Am. J. Psychiat. 159:2002;456-459.
Shimokata R.A., Tobin J.D., Muller D.C., Elahi D., Coon R.J., Andres R. Studies on the distribution of body fat: effects of age, sex and obesity. J. Gerontol. Med. Sci. 44:1989;1466-1473.
Skakkebaek N.E., Bancroft J., Davidson D.W., Warner P. Androgen replacement with oral testosterone undecanoate in hypogonadal men: a double blind controlled study. Clin. Endocrinol. 14:1981;49-61.
Skolnick A.A. Is male menopause real or just an excuse? J.A.M.A. 268:1992;2486.
Sodergard R., Backstrom T., Shanbhag V., Carstensen H. Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J. Steroid. Biochem. 16:1982;801-810.
Steiger A., von Bardeleben U., Weidemann K., Holsboer F. Sleep EEG and nocturnal secretion of testosterone and cortisol in patients with major endogenous depression during acute phase and after remission. J. Psychiatr. Res. 25:1991;169-177.
Sternbach H. Age-associated testosterone decline in men. Am. J. Psychiat. 155:1998;1310-1318.
Tenover J.L. Male hormone replacement therapy including "andropause" Endocrinol. Metab. Clin. North Am. 27:1998;969-987.
The WHOQOL group, 1998. Development of the World Health Organization WHOQOL-BREF quality of life assessment. The WHOQOL group. Psychol. Med. 28, 551-558.
Unden F., Ljunggren J.G., Beck-Friis J., Kjellman B.F., Wetterberg L. Hypothalamic-pituitary-gonadal axis in major depressive disorders. Acta Psychiatr. Scand. 78:1988;138-146.
Vermeulen A. Androgen replacement therapy in the aging male. a critical evaluation. J. Clin. Endocrinol. Metab. 86:2001;2380-2390.
Vermeulen A. Andropause. Marturitas. 34:2000;5-15.
Vermeulen A., Deslypere J.P., Kaufman J.M. L'andropause: mythe ou réalité? Contracept. Fertil. Sex. 17:1989;473-477.
Vermeulen A., Goemaere S., Kaufman J.M. Testosterone, body composition and aging. J. Endocrinol. Invest. 22:1999;110-116.
Vermeulen A., Verdonck L., Kaufman J.M. A critical evaluation of simple methods for the estimation of free testosterone in serum. J. Clin. Endocrinol. Metab. 84:1999;3666-3672.
Vogel W., Klaiber E.L., Broverman D.M. Roles of the gonadal steroid hormones in psychiatric depression in men and women. Prog. Neuropsychopharmacology. 2:1978;487-503.
Wang C., Alexander G., Berman N., Salehian B., Davidson T., McDonald V., Steiner B., Hull L., Callegari C., Swerdloff R.S. Testosterone replacement therapy improves mood in hypogonadal men: a clinical research center study. J. Clin. Endocrinol. Metab. 81:1996;3578-3583.
Wang, C., Swerdloff, R.S., Iranmanesh, A., Dobs, A., Snyder, P.J., Cunningham, G., Matsumoto, A.M., Weber, T., Berman, N., the Gel Study Group., 2000. Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition. Parameters in hypogonadal men. J. Clin. Endocrinol. Metab. 85, 2839-2853.
Winters, S.J., Atkinson, L., For the Testoderm Study Group, 1997. Serum LH concentrations in hypogonadal men during transdermal testosterone replacement through scrotal skin: further evidence that aging enhances testosterone negative feedback. Clin. Endocrinol. (Oxf) 47, 317-322.
Wu F.C., Bancroft J., Davidson D.W., Nical K. The behavioural effects of testosterone undecanoate in adult men with Klinefelter's syndrome: a controlled study. Clin. Endocrinol. 16:1982;489-497.
Wu C.Y., Yu T.J., Chen M.J. Age related testosterone level changes and male andropause syndrome. Changgeng Yi Xue Za Zhi. 23:2000;348-353.
Yesavage J.A., Davidson J., Widrow L., Berger P.A. Plasma testosterone levels, depression, sexuality, and age. Biol Psychiat. 20:1985;222-225.