Reference : Comparison of inhibitory functioning in mild Alzheimer's disease and frontotemporal d...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/5940
Comparison of inhibitory functioning in mild Alzheimer's disease and frontotemporal dementia
English
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie >]
Amieva, Hélène [>Université V. Segalen, Bordeaux > > >Inserm U593 > > >]
Adam, Stéphane mailto [Université de Liège - ULg > Département des sciences cognitives > Département des sciences cognitives >]
Hogge, Michaël [Université de Liège - ULg > Département des Sciences Cognitives > Neuropsychologie > >]
Van der Linden, Martial mailto [Université de Liège - ULg > Département des sciences cognitives > Psychopathologie cognitive >]
Fabrigoule, Colette [>Université V. Segalen, Bordeaux > > >Insem U593 > > > >]
Salmon, Eric mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Oct-2007
Cortex : A Journal Devoted to the Study of the Nervous System & Behavior
Elsevier Masson
43
7
866-874
Yes (verified by ORBi)
International
0010-9452
Milano
[en] inhibition ; frontotemporal dementia ; Alzheimer's disease ; executive functions
[en] Executive dysfunction is frequently reported in Alzheimer's disease (AD) and the frontal variant of frontotemporal dementia (FTD). More specifically, inhibitory dysfunction is observed early in AD and inhibitory deficits are also prominent in patients with FTD. However, few studies have simultaneously explored and compared inhibitory abilities in both degenerative diseases. Consequently, the aim of this study was to compare verbal and motor inhibitory processes in the initial stages of AD and the frontal variant of FTD. Stroop and Go/No-go tasks were administered. The results demonstrate that, on the Go/No-go task, AD and FTD patients do not produce more errors than control subjects. However, both groups are impaired on the Stroop task (mainly with regard to the error score) but do not differ from each other. These results indicate that AD and FTD patients do not present a general impairment of their inhibitory abilities. Moreover, these two kinds of dementia present similar quantitative and qualitative inhibitory impairments on the two tasks, although their patterns of structural and functional cerebral impairments are known to be different. The presence of similar inhibitory deficits despite very different patterns of brain damage is in agreement with the hypothesis that inhibitory dysfunction in the two groups of patients depends on a disconnection process between anterior and posterior cerebral areas, rather than on the presence of focal metabolism decreases in different regions.
Researchers
http://hdl.handle.net/2268/5940
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B8JH1-4S0JBR2-6&_user=532038&_coverDate=12%2F31%2F2007&_rdoc=6&_fmt=high&_orig=browse&_srch=doc-info(%23toc%2343685%232007%23999569992%23682590%23FLP%23display%23Volume)&_cdi=43685&_sort=d&_docanchor=&_ct=18&_acct=C000026659&_version=1&_urlVersion=0&_userid=532038&md5=b532c8fe58ab5854a27c55313d4f9165
Site du journal: http://www.elsevier.com/wps/find/journaldescription.cws_home/714334/description#description

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Collette_Cortex_06_postprint.pdfPublisher postprint182.52 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.