Reference : Tumor ZAC1 expression is associated with the response to somatostatin analog therapy ...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/59309
Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly.
English
Theodoropoulou, Marily [Max Planck Institute of Psychiatry > Department of Endocrinology > > >]
Tichomirowa, Maria A [Centre Hospitalier Universitaire de Liège - CHU > Department of Endocrinology > > >]
Sievers, Caroline [Max Planck Institute of Psychiatry > Department of Endocrinology > > >]
Yassouridis, Alexander [Max Planck Institute of Psychiatry > Research Group of Statistics > > >]
Arzberger, Thomas [Munchen Ludwig-Maximilians-University > Center for Neuropathology and Prion Research > > >]
Hougrand, Olivier [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
Deprez, Manuel [Université de Liège - ULg > Département des sciences cliniques > Neuropathologie >]
Daly, Adrian [Université de Liège - ULg > Département des sciences cliniques > Endocrinologie >]
Petrossians, Patrick [Centre Hospitalier Universitaire de Liège - CHU > > Endocrinologie clinique >]
Pagotto, Uberto [Center for Applied Biomedical Research Orsola-Malpighi General Hospital Italy > Department of Internal Medicine and Gastroenterology > > >]
Beckers, Albert mailto [Université de Liège - ULg > Département des sciences cliniques > Endocrinologie >]
Stalla, Gunter K [Max Planck Institute of Psychiatry > Department of Endocrinology > > >]
Nov-2009
International Journal of Cancer = Journal International du Cancer
Wiley Liss, Inc.
125
9
2122-6
Yes (verified by ORBi)
International
0020-7136
1097-0215
New York
NY
[en] Acromegaly/drug therapy ; Adolescent ; Adult ; Aged ; Cell Cycle Proteins/analysis ; Cohort Studies ; Female ; Human Growth Hormone/blood ; Humans ; Insulin-Like Growth Factor I/analysis ; Male ; Middle Aged ; Octreotide/therapeutic use ; Peptides, Cyclic/therapeutic use ; Pituitary Neoplasms/chemistry/drug therapy ; Retrospective Studies ; Somatostatin/analogs & derivatives/therapeutic use ; Transcription Factors/analysis ; Tumor Suppressor Proteins/analysis
[en] Somatostatin analogs (SSA) with their potent antisecretory and antiproliferative effects are the main medical treatment option for patients with neuroendocrine tumors, such as gastroenteropancreatic and acromegaly-associated growth hormone secreting pituitary tumors. Although a good portion of acromegalic patients gets normalized after SSA treatment, strict hormonal control is not achieved in a sizeable proportion of these patients. The reasons for this incomplete response to SSA treatment are unclear. We have found that the tumor suppressor ZAC1 (LOT1/PLAGL1) is essential for the antiproliferative effect of SSA in pituitary tumor cells. The aim of the present retrospective cohort study was to determine whether ZAC1 immunoreactivity in archival somatotrophinoma tissue derived from 45 patients with acromegaly routinely pretreated with SSA before surgery, was associated with response to SSA (normalization of GH, IGF-I and presence of tumor shrinkage). All tumors displayed ZAC1 immunoreactivity [weak (+; n = 15), moderate (++; n = 16) and strong (+++; n = 14)]. A significant positive correlation was found between strong ZAC1 immunoreactivity and IGF-I normalization and presence of tumor shrinkage after SSA treatment, which was not affected by age at diagnosis, gender or duration of SSA treatment. These in vivo data combined with the antiproliferative properties of ZAC1/Zac1 provide evidence of a mechanistic role for this transcription factor on SSA induced tumor shrinkage and hormone normalization.
Deutsche Forschungsgemeinschaft - DFG, Novartis Pharma GmbH, Nurnberg, Germany
Researchers ; Professionals
http://hdl.handle.net/2268/59309
10.1002/ijc.24602
Publisher's version/PDF cannot be used
Publisher source must be acknowledged
Must link to publisher version with set statement [The definitive version is available at www3.interscience.wiley.com] author can archive post-print (ie final draft post-refereeing
(c) 2009 UICC.

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Tumor ZAC1 expression is associated with the response to somatostatin analog.pdfAuthor postprint362.56 kBView/Open
Restricted access
Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly..pdfPublisher postprint197.17 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.