Reference : Population dynamics of CD4+ T cells lacking Thy-1 in murine retrovirus-induced immunodef...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/59276
Population dynamics of CD4+ T cells lacking Thy-1 in murine retrovirus-induced immunodeficiency syndrome (MAIDS).
English
Moutschen, Michel mailto [Centre Hospitalier Universitaire de Liège - CHU > > Maladies infectieuses et médecine interne générale >]
Colombi, S. [University of Liege, Liege, Belgium > Department of Pathology. > > >]
Deprez, Manuel [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Van Wijk, F. [Centre Hospitalier Universitaire de Liège - CHU > Department of Pathology. > > >]
Hotermans, C. [Centre Hospitalier Universitaire de Liège - CHU > Department of Pathology. > > >]
Martin, Michel mailto [Centre Hospitalier Universitaire de Liège - CHU > > Exploitation technique-maintenance des bâtiments >]
Greimers, Roland [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
Boniver, Jacques mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
1994
Scandinavian Journal of Immunology
Blackwell Publishing
39
2
216-24
Yes (verified by ORBi)
International
0300-9475
1365-3083
Oxford
United Kingdom
[en] Animals ; Antigens, CD3/analysis ; Antigens, CD44 ; Antigens, Surface/analysis ; Antigens, Thy-1 ; CD4-Positive T-Lymphocytes/immunology ; Carrier Proteins/analysis ; Leukocyte Count ; Lymph Nodes/immunology ; Male ; Membrane Glycoproteins/analysis ; Mice ; Mice, Inbred C57BL ; Murine Acquired Immunodeficiency Syndrome/immunology ; Phenotype ; Receptors, Antigen, T-Cell, alpha-beta/analysis ; Receptors, Cell Surface/analysis ; Receptors, Lymphocyte Homing/analysis ; Spleen/immunology ; T-Lymphocyte Subsets/immunology
[en] Increased numbers of CD4+ Thy-1- cells have been described in the spleen (SP) of mice with retrovirus-induced immunodeficiency (MAIDS). Since this phenotypic abnormality might have considerable functional importance, the expansion of the CD4+ Thy-1- subset in MAIDS was characterized further. CD4+ Thy-1- and Thy-1+ T-cells from infected mice expressed similar densities of CD3 and TCR alpha/beta. In contrast, the Thy-1- subset was uniformly CD44hi, even early in the disease when part of Thy-1+ cells were still CD44lo. The emergence of CD4+ Thy-1- cells occurred first in SP and lymph nodes and was observed later in thymus. The important fraction of CD4+ cells lacking Thy-1 normally present in Peyer's patches was only weakly modified. Despite the major expansion of the CD4+ Thy-1- phenotype, the proliferating fraction was not higher in this subset than in CD4+ Thy-1+ cells from infected mice. Persistence after hydroxyurea administration was identical in both subsets, indicating similar mean cell lifespans. Taken together, these results show that the major expansion of CD4+ Thy-1- T-cells in MAIDS is not ascribable solely to increased proliferation within this subset. Phenotypic analysis suggests that CD4+ Thy-1- cells result from the differentiation of Thy-1+ cells induced by activation signals related to retroviral infection.
Researchers ; Professionals
http://hdl.handle.net/2268/59276
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