Reference : PCAM: a multi-user facility-based protein crystallization apparatus for microgravity
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/59036
PCAM: a multi-user facility-based protein crystallization apparatus for microgravity
English
Carter, Daniel [New Century Pharmaceuticals, Inc., Huntsville > > > >]
Wright, Brenda [New Century Pharmaceuticals, Inc., Huntsville > > > >]
Miller, Teresa [Marshall Space Flight Center, Huntsville, > > > >]
Chapman, Jenny [New Century Pharmaceuticals, Inc., Huntsville > > > >]
Twigg, Pam [New Century Pharmaceuticals, Inc., Huntsville > > > >]
Keeling, Kim [New Century Pharmaceuticals, Inc., Huntsville > > > >]
Moody, Kerry [New Century Pharmaceuticals, Inc., Huntsville > > > >]
White, Melissa [New Century Pharmaceuticals, Inc., Huntsville > > > >]
Click, James [New Century Pharmaceuticals, Inc., Huntsville > > > >]
Ruble, John [New Century Pharmaceuticals, Inc., Huntsville > > > >]
Ho, Joseph [New Century Pharmaceuticals, Inc., Huntsville > > > >]
Adcock-Downey, Lawana [New Century Pharmaceuticals, Inc., Huntsville > > > >]
Dowling, Tim [Marshall Space Flight Center, Huntsville > > > >]
Chang, Chong-Hwan [DuPont Pharmaceuticals Company, Wilmington > > > >]
Ala, Paul [DuPont Pharmaceuticals Company, Wilmington > > > >]
Rose, John [University of Georgia, Athens > > > >]
Wang, B. C. [University of Georgia, Athens > > > >]
Declercq, Jean-Paul mailto [Université Catholique de Louvain - UCL > Département de Chimie > Laboratoire de Chimie Physique et de Cristallographie > >]
Evrard, Christine mailto [Université Catholique de Louvain - UCL > Département de Chimie > Laboratoire de Chimie Physique et de Cristallographie > >]
Rosenberg, John [University of Pittsburgh > > > >]
Wery, Jean-Pierre [Lilly Corporate Center, Indianapolis > > > >]
Clawson, David [Lilly Corporate Center, Indianapolis > > > >]
Wardell, Mark [Washington University > > > >]
Stallings, W. [Monsanto/Searle BB4K, St. Louis > > > >]
Stevens, A. [Monsanto/Searle BB4K, St. Louis > > > >]
1999
Journal of Crystal Growth
Elsevier Science
196
610-622
Yes (verified by ORBi)
International
0022-0248
Amsterdam
The Netherlands
[en] PCAM ; Protein ; Crystal ; Microgravity ; Vapor-diffusion ; Shuttle
[en] A facility-based protein crystallization apparatus for microgravity (PCAM) has been constructed and flown on a series of Space Shuttle Missions. The hardware development was undertaken largely because of the many important examples of quality improvements gained from crystal growth in the diffusion-limited environment in space. The concept was based on the adaptation for microgravity of a commonly available crystallization tray to increase sample density, to facilitate co-investigator participation and to improve flight logistics and handling. A co-investigator group representing scientists from industry, academia, and government laboratories has been established. Microgravity applications of the hardware have produced improvements in a number of structure-based crystallographic studies and include examples of enabling research. Additionally, the facility has been used to support fundamental research in protein crystal growth which has delineated factors contributing to the effect of microgravity on the growth and quality of protein crystals.
http://hdl.handle.net/2268/59036
http://www.elsevier.com/wps/find/journaldescription.cws_home/505670/description#description

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