Reference : Elongator controls the migration and differentiation of cortical neurons through acet...
Scientific journals : Article
Human health sciences : Neurology
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/5901
Elongator controls the migration and differentiation of cortical neurons through acetylation of a tubulin
English
[fr] Elongator contrôle la migration des neurones du coretx via l'acétylation de l'alpha tubuline
Creppe, Catherine mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Malinouskaya, Lina mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Volvert, Marie-Laure [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Gillard, Magali [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Close, Pierre mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Malaise, Olivier mailto [Université de Liège - ULg > > > Cert.ECG]
Laguesse, Sophie [> >]
Cornez, Isabelle [> >]
Rahmouni, Souad mailto [Université de Liège - ULg > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén. >]
Ormenese, Sandra mailto [Université de Liège - ULg > > GIGA-Management : Plate-forme imagerie >]
Belachew, Shibeshih mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie - CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. >]
Malgrange, Brigitte mailto [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. - Neurologie >]
Chapelle, Jean-Paul mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Siebenlist, Ulrich [> >]
Moonen, Gustave mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine >]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Nguyen, Laurent mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
6-Feb-2009
Cell
Cell Press
136
551-564
Yes (verified by ORBi)
International
0092-8674
1097-4172
Cambridge
MA
[en] Elongator ; alpha tubuline ; migration
[en] The generation of cortical projection neurons relies on the coordination of radial migration with branching. Here we report that the multi-subunit histone acetyltransferase Elongator complex, which contributes to transcript elongation, also regulates the maturation of projection neurons. Indeed, silencing of its scaffold (Elp1) or catalytic subunit (Elp3) cell-autonomously delays the migration and impairs the branching of projection neurons. Strikingly, neurons defective in Elongator show reduced levels of acetylated alpha tubulin. A direct reduction of alpha tubulin acetylation leads to comparable defects in cortical neurons and suggests that alpha tubulin is a target of Elp3. This is further supported by the demonstration that Elp3 promotes acetylation and counteracts HDAC6-mediated deacetylation of this substrate in vitro. Our results uncover alpha tubulin as a target of the Elongator complex and suggest that a tight regulation of its acetylation underlies the maturation of cortical projection neurons.
Giga-Signal Transduction ; Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; TELEVIE ; ARC-ULG ; PAI Phase VI ; Fonds Léon Fredericq (Prix Suez) ; FBC
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/5901

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