Reference : System Analysis of a Programmed Cell Death Model
Scientific congresses and symposiums : Paper published in a journal
Engineering, computing & technology : Multidisciplinary, general & others
http://hdl.handle.net/2268/58372
System Analysis of a Programmed Cell Death Model
English
Bullinger, Eric mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Méthodes computationnelles pour la biologie systémique >]
Dec-2005
IEEE Conference on Decision and Control
IEEE
7994-7999
Yes
No
International
0191-2216
44th IEEE Conference on Decision and Control, and the European Control Conference 2005
12-15 December 2005
Seville
Spain
[en] Apoptosis is a programmed cell death by which
the organism removes unwanted cells. Its core reactions can
be described by a system of differential equations exhibiting
multiple steady-states. In this paper we analyse how this model
can include both very slow dynamics for the lag phase before
apoptosis (in theory up to several days) while the apoptosis itself
is more switch-like with changes occurring within minutes. We
both describe how the trajectories evolve during the lag phase
and show which of the states have the most impact on the slow
dynamics.
http://hdl.handle.net/2268/58372
http://ieeexplore.ieee.org/iel5/10559/33412/01583455.pdf?tp=&isnumber=33412&arnumber=1583455&punumber=10559

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