| Reference : System Analysis of a Programmed Cell Death Model |
| Scientific congresses and symposiums : Paper published in a journal | |||
| Engineering, computing & technology : Multidisciplinary, general & others | |||
| http://hdl.handle.net/2268/58372 | |||
| System Analysis of a Programmed Cell Death Model | |
| English | |
Bullinger, Eric [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Méthodes computationnelles pour la biologie systémique >] | |
| Dec-2005 | |
| IEEE Conference on Decision and Control | |
| IEEE | |
| 7994-7999 | |
| No | |
| International | |
| 0191-2216 | |
| 44th IEEE Conference on Decision and Control, and the European Control Conference 2005 | |
| 12-15 December 2005 | |
| Seville | |
| Spain | |
| [en] Apoptosis is a programmed cell death by which
the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this paper we analyse how this model can include both very slow dynamics for the lag phase before apoptosis (in theory up to several days) while the apoptosis itself is more switch-like with changes occurring within minutes. We both describe how the trajectories evolve during the lag phase and show which of the states have the most impact on the slow dynamics. | |
| http://hdl.handle.net/2268/58372 | |
| http://ieeexplore.ieee.org/iel5/10559/33412/01583455.pdf?tp=&isnumber=33412&arnumber=1583455&punumber=10559 |
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