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System Analysis of a Programmed Cell Death Model
Bullinger, Eric
2005In IEEE Conference on Decision and Control, p. 7994-7999
Peer reviewed
 

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Abstract :
[en] Apoptosis is a programmed cell death by which the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this paper we analyse how this model can include both very slow dynamics for the lag phase before apoptosis (in theory up to several days) while the apoptosis itself is more switch-like with changes occurring within minutes. We both describe how the trajectories evolve during the lag phase and show which of the states have the most impact on the slow dynamics.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Bullinger, Eric ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Méthodes computationnelles pour la biologie systémique
Language :
English
Title :
System Analysis of a Programmed Cell Death Model
Publication date :
December 2005
Event name :
44th IEEE Conference on Decision and Control, and the European Control Conference 2005
Event place :
Seville, Spain
Event date :
12-15 December 2005
Audience :
International
Journal title :
IEEE Conference on Decision and Control
ISSN :
0191-2216
Publisher :
IEEE
Pages :
7994-7999
Peer reviewed :
Peer reviewed
Available on ORBi :
since 28 May 2010

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