ORBi: Fumal Arnaud - Induction of long-lasting changes of visual cortex excitability by five daily sessions of repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers and migraine patients

Reference : Induction of long-lasting changes of visual cortex excitability by five daily sessions o...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Neurology Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/58165

Title :	Induction of long-lasting changes of visual cortex excitability by five daily sessions of repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers and migraine patients
Language :	English
Author, co-author :	Fumal, Arnaud [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR >]
	Coppola, G. [> > > >]
	Bohotin, V. [> > > >]
	Gérardy, Pierre-Yves [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
	Seidel, Laurence [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique >]
	Donneau, Anne-Françoise [Université de Liège - ULg > Département des sciences de la santé publique > Département des sciences de la santé publique >]
	Vandenheede, Michel [> >]
	Maertens De Noordhout, Alain [Université de Liège - ULg > > Neurologie CHR >]
	Schoenen, Jean [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie]
Publication date :	Feb-2006
Journal title :	Cephalalgia : An International Journal of Headache
Publisher :	Blackwell Science
Volume :	26
Issue/season :	2
Pages :	143-149
Audience :	International
ISSN :	0333-1024
Keywords :	[en] habituation ; healthy volunteers ; migraine ; preventative therapy ; repetitive transcranial magnetic stimulation ; visual evoked potentials
Abstract :	[en] We have shown that in healthy volunteers (HV) one session of 1 Hz repetitive transcranial magnetic stimulation (rTMS) over the visual cortex induces dishabituation of visual evoked potentials (VEPs) on average for 30 min, while in migraineurs one session of 10 Hz rTMS replaces the abnormal VEP potentiation by a normal habituation for 9 min. In the present study, we investigated whether repeated rTMS sessions (1 Hz in eight HV; 10 Hz in eight migraineurs) on 5 consecutive days can modify VEPs for longer periods. In all eight HV, the 1 Hz rTMS-induced dishabituation increased in duration over consecutive sessions and persisted between several hours (n = 4) and several weeks (n = 4) after the fifth session. In six out eight migraineurs, the normalization of VEP habituation by 10 Hz rTMS lasted longer after each daily stimulation but did not exceed several hours after the last session, except in two patients, where it persisted for 2 days and 1 week. Daily rTMS can thus induce long-lasting changes in cortical excitability and VEP habituation pattern. Whether this effect may be useful in preventative migraine therapy remains to be determined.
Permalink :	http://hdl.handle.net/2268/58165
DOI :	10.1111/j.1468-2982.2005.01013.x

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