Reference : Evaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial pr...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/57327
Evaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties.
English
Jansen, Olivia mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Tits, Monique mailto [Université de Liège - ULg > Département de pharmacie > Phytochimie et phytothérapie >]
Nicolas, Jean Pierre [Association jardins du monde > > > >]
De Mol, Patrick mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale >]
Nikiéma, J. B. [ > > ]
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
2010
Journal of Ethnopharmacology
Elsevier Sequoia
130
143-150
Yes (verified by ORBi)
International
0378-8741
1872-7573
Limerick
Ireland
[en] AIM OF THE STUDY: The aim of this study was to evaluate the antiplasmodial properties of 13 plants used against malaria in traditional medicine in Burkina Faso. MATERIALS AND METHODS: In vitro antiplasmodial activity of dichloromethane, methanol and aqueous crude extracts obtained from vegetal samples collected in Burkina Faso was first evaluated on the Plasmodium falciparum 3D7 chloroquine-sensitive strain using a colorimetric method. RESULTS: Thirteen extracts obtained from 8 different species were found to exhibit antiplasmodial activity (IC(50)<50mug/ml). Five species demonstrated a moderate activity (15mug/ml<IC(50)<50mug/ml): Boswellia dalzielii (leaves), Waltheria indica (roots and aerial parts), Bergia suffruticosa (whole plant), Vitellaria paradoxa (bark) and Jatropha gossypiifolia (leaves). The best results were obtained with extracts from the Dicoma tomentosa whole plant, from Psorospermum senegalense leaves and from Gardenia sokotensis leaves. These extracts found to display promising antiplasmodial activity, with IC(50) values ranging from 7.0 to 14.0mug/ml. The most active plant extracts were then tested for in vitro activity on the Plasmodium falciparum W2 chloroquine-resistant strain and also for in vitro cytotoxicity on normal human fibroblasts (WI-38) in order to determine the selectivity index. CONCLUSIONS: Dicoma tomentosa (Asteraceae) and Psorospermum senegalense (Clusiaceae) appeared to be the best candidates for further investigation of their antiplasmodial properties, reported for the first time by this study.
http://hdl.handle.net/2268/57327
10.1016/j.jep.2010.04.032
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

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