Reference : Effect of treatment with octreotide on the morphology of growth hormone secreting pit...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/57157
Effect of treatment with octreotide on the morphology of growth hormone secreting pituitary adenomas : study of 24 cases.
English
Beckers, Albert mailto [Université de Liège - ULg > Département des sciences cliniques > Endocrinologie >]
Kovacs, K. [ > > ]
Horvwarth, E. [ > > ]
Abs, R. [ > > ]
Reznik, Michel [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Stevenaert, Achille [Université de Liège - ULg > > Neurochirurgie >]
Sep-1991
Endocrine Pathology
Humana Press
2
3
123-131
Yes (verified by ORBi)
International
1046-3976
1559-0097
Totowa
NJ
[en] acromegalic patients ; octreotide subcutaneously ; transsphenoidal surgery
[en] Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological studies performed in 19 patients before and at the end of this treatment period revealed no changes in 8 cases. In 8 other cases, a slight reduction in tumorsize was observed, and in 3 cases an important shrinkage was documented. At surgery, the adenomatous tissue appeared softer than in nonpretreated patients, facilitating the operation. Pathological examination revealed widening of perivascular spaces with accumulation of fibrous tissue and more crinophagy than in nonpretreated patients but failed to reveal morphologically pronounced cell involution as observed in prolactin-producing adenomas treated with dopamine agonists. No significant difference in frequency or extent of cellular changes was noted between the two groups. These morphological findings seem to be more consistent with a functional inhibition of growth hormone release than with cellular alterations induced by octreotide.
Researchers ; Professionals
http://hdl.handle.net/2268/57157
10.1007/BF02915452

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