Reference : Cyclical Cushing's disease : a case report.
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/57153
Cyclical Cushing's disease : a case report.
English
Velkeniers, B. [ > > ]
Beckers, Albert mailto [Université de Liège - ULg > Département des sciences cliniques > Endocrinologie >]
Stevenaert, Achille [Université de Liège - ULg > > Neurochirurgie >]
Smits, J. [ > > ]
Finne, E. [ > > ]
Vanhaelst, L. [ > > ]
Jun-1991
Pathology - Research & Practice
Gustav Fischer Verlag
187
5
603-607
Yes (verified by ORBi)
International
0344-0338
Stuttgart
Germany
[en] Cushing's syndrome ; ACTH hypersecretion ; biochemical remission ; clinical remissino ; Cushing's disease ; circadian hyperpulsatile ACTH ; cortisol secretion
[en] A 41-year-old man with clinical Cushing's syndrome and intermittent central ACTH hypersecretion for a period of 9 1/2 years follow-up is described. Episodes of biochemical and clinical remission alternated with periods of florid Cushing's disease, characterized by circadian hyperpulsatile ACTH and cortisol secretion. Responses to metyrapone and inhibition of ACTH and cortisol hypersecretion after high dose dexamethasone during active phases of the disease favored a central origin of ACTH hypersecretion, confirmed by simultaneous bilateral venous sampling of the sinus petrosus inferior. Prolonged clinical remission followed near total anterior hypophysectomy. However, on anatomopathological examination of the pituitary neither corticotroph cell hyperplasia nor a microadenoma could be documented. The possibility of a functional ACTH hypersecretion is discussed.
Researchers ; Professionals
http://hdl.handle.net/2268/57153

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