Reference : Cyclical Cushing's disease : a case report.
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Cyclical Cushing's disease : a case report.
Velkeniers, B. [ > > ]
Beckers, Albert mailto [Université de Liège - ULg > Département des sciences cliniques > Endocrinologie >]
Stevenaert, Achille [Université de Liège - ULg > > Neurochirurgie >]
Smits, J. [ > > ]
Finne, E. [ > > ]
Vanhaelst, L. [ > > ]
Pathology - Research & Practice
Gustav Fischer Verlag
Yes (verified by ORBi)
[en] Cushing's syndrome ; ACTH hypersecretion ; biochemical remission ; clinical remissino ; Cushing's disease ; circadian hyperpulsatile ACTH ; cortisol secretion
[en] A 41-year-old man with clinical Cushing's syndrome and intermittent central ACTH hypersecretion for a period of 9 1/2 years follow-up is described. Episodes of biochemical and clinical remission alternated with periods of florid Cushing's disease, characterized by circadian hyperpulsatile ACTH and cortisol secretion. Responses to metyrapone and inhibition of ACTH and cortisol hypersecretion after high dose dexamethasone during active phases of the disease favored a central origin of ACTH hypersecretion, confirmed by simultaneous bilateral venous sampling of the sinus petrosus inferior. Prolonged clinical remission followed near total anterior hypophysectomy. However, on anatomopathological examination of the pituitary neither corticotroph cell hyperplasia nor a microadenoma could be documented. The possibility of a functional ACTH hypersecretion is discussed.
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